OBJECTIVE This study was designed to compare glucose, lipids, and C-reactive protein (CRP) in women with gestational diabetes mellitus treated with metformin or insulin and in cord plasma of their offspring and to examine how these markers relate to infant size at birth. RESEARCH DESIGN AND METHODS Women with gestational diabetes mellitus were randomly assigned to metformin or insulin in the ...

Diabetes is a common problem in approximately 7.6% of pregnant women older than 20 years in Brazil. Results from human and rodent diabetic experimental models have suggested that the placenta is a compromised target, which largely suffers the impact of maternal diabetes. In view of the importance of diabetes for maternal and neonatal health, the objective of the present study was to assess mate...

OBJECTIVE Diabetes in pregnancy has been shown to increase in parallel with the increasing prevalence of obesity. In this national population-based study, we analyzed the trends for gestational diabetes mellitus (GDM), type 1 diabetes in pregnancy, and type 2 diabetes in pregnancy in Sweden between 1998 and 2012. RESEARCH DESIGN AND METHODS A population-based cohort study using the Swedish na...

Understanding the experiences of a pragmatic lifestyle intervention for women with gestational diabetes mellitus and overweight/obesity to reduce maternal weight at 12 months postpartum - Volume 82 Issue OCE4

OBJECTIVE: Low-grade systemic inflammation is associated with an increased risk of type 2 diabetes. C-Reactive Protein (CRP), an acute phase protein produced by hepatocytes, may be associated with diabetes. This study aimed to compare serum levels of CRP in women with gestational diabetes mellitus (GDM), impaired glucose tolerance test and control subjects. MATERIALS AND METHODS: In this ca...

background despite improvements in medical care provided during pregnancy to diabetic mothers, the cardiac complications in their infants are still more frequent than in the infants of general population. conclusions our data showed a high prevalence of chd in idms in our pediatric cardiology clinic. neither the types of maternal diabetes nor the somatic findings of newborns were related to the...

INTRODUCTION Diabetes in pregnancy threatens both maternal and neonatal health, with risks of lung immaturity, fetal macrosomia, dystocia and impaired maternal kidney function. Before insulin, diabetes resulted in maternal mortality rates of 30-50% and perinatal mortality rates of 50-60%. Global prevalence estimates vary by population, geographical area and diagnostic criteria. Diabetes account...

The objective of this study was to describe the reproductive profile of women with diabetes mellitus (DM) and to identify their knowledge regarding maternal and fetal risks and preconception care. This exploratory study was performed at the Integrated Center for Hypertension and Diabetes, from March to July 2009, on a sample consisting of 106 women. The variables were: number of pregnancies, bi...

It is suggested that the maternal transmission of islet autoantibodies increases the risk of autoimmune diabetes in mice. The aim of this study was to determine whether fetal exposure to islet autoantibodies modified the risk of type 1 diabetes in humans. Islet autoantibodies were measured at birth in 720 offspring of mothers with type 1 diabetes. Offspring were prospectively followed for the d...

BACKGROUND Anorectal malformations (ARM) are rare forms of congenital uro-rectal anomalies with largely unknown causes. Besides genetic factors, prenatal exposures of the parents to nicotine, alcohol, caffeine, illicit drugs, occupational hazards, overweight/obesity and diabetes mellitus are suspected as environmental risk factors. METHODS Relevant studies published until August 2010 were ide...