Tablets containing metoprolol succinate and Compritol(®) 888ATO in the ratio of 1:2 yielded the desired sustained release profile in phosphate buffer pH 6.8 when evaluated using USP type II paddle apparatus and was selected as the optimized formulation. Robustness of optimized formulation was assessed by studying the effect of factors like varying source of metoprolol succinate and Compritol(®)...

In the present investigation, an attempt has been made to increase therapeutic efficacy, reduce frequency of administration and improve patient compliance by developing sustained release matrix tablets of theophylline. Sustained release matrix tablets of theophylline were developed by using drug and different concentrations of polymer such as 10, 20, 30, 40 and 50%. Hydroxypropylmethylcellulose...

a sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. in this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose (ec), eudragit rs100 (rs), and eudragit s100 (s) were prepared by direct compression. the release behaviors were then studied in two co...

Preparation of matrix tablets with rate controlling polymers is the simplest and most widely used method for achieving desired controlled release rate of drugs. The objective of the present study was to evaluate the effect of concentration and particle size of Ethocel Premium 100P and 100FP and also the co-excipients like HPMC, starch and CMC on the release kinetics of Tramadol HCl from matrix ...

PURPOSE OF STUDY: In the present study, an attempt was made to increase therapeutic effectiveness, reduction in dosing frequency and thus improving patient compliance, by developing sustained release matrix tablets of Diclofenac sodium using guar gum as release modifier. METHOD: Six batches of sustained release matrix tablets of Diclofenac sodium was prepared by using different drug: polymer ra...

The prolonged release gliclazide matrix tablets were prepared using polymeric materials, namely, HPMC, Kollidon SR, Carbopol with Xanthan gum, Eudragit RSPO and Eudragit RLPO. HPMC, Kollidon SR and Carbopol with Xanthan gum were able to retard gliclazide release from matrix tablets in a concentration dependent manner, but the rate of retardation differed among the polymers. On the other hand, d...

This study evaluated the in vitro potential of cocoa pod husk (CPH) pectin as a carrier for chronodelivery of hydrocortisone intended for adrenal insufficiency. FTIR studies found no drug-CPH pectin interactions, and chemometric analysis showed that pure hydrocortisone bears closer similarity to hydrocortisone in hot water soluble pectin (HWSP) than hydrocortisone in citric acid soluble pectin ...

Objective: The present research is focused on developing flurbiprofen colon-specific tablets based on timed release and pH-sensitivity. Methods and Material: This study is designed to study the effect of eudragit coating on the drug release from hydroxypropyl methylcellulose matrix to achieve the colon-specific release. Hydroxypropyl methylcellulose matrix tablets were prepared by wet granulati...

Purpose: To develop and optimize controlled-release (CR) oxybutynin chloride matrix tablets. Methods: Oxybutynin CR tablets were prepared by embedding drug-containing granules into a hydrogel matrix of hydroxypropyl methylcellulose (HPMC). A coating layer was then applied with a mixture of HPMC, ethylcellulose, shellac, and HPMC phthalate. The effect of several formulation variables on in vitro...

The dissolution characteristics of melt granulations of paracetamol in capsule and tablet dosage form were compared to determine whether the dissolution characteristics of the granules can be actualized by formulating them as rapidly disintegrating tablets. The term melt granulation refers here to the wax-matrix granules that were formed by triturating the drug powder (paracetamol) with a melte...