There is a strong genetic risk for late-onset Alzheimer's disease (AD), but so far few gene variants have been identified that reliably contribute to that risk. A newly confirmed genetic risk allele C of the clusterin (CLU) gene variant rs11136000 is carried by ∼88% of Caucasians. The C allele confers a 1.16 greater odds of developing late-onset AD than the T allele. AD patients have reductions...

The IEC standards 61508/61511 require that reliability targets for safety instrumented functions are defined and verified. The reliability targets are given as one out of a possible four safety integrity levels. For each safety integrity level there are many design requirements, including requirements for the probability of failure on demand. Verification of the requirements for the probability...

Static integrity constraints involve only the current database state. Temporal integrity constraints involve current, past, and future database states; they can be expressed by essentially unrestricted sentences in temporal logic. Certain syntactically restricted classes of temporal constraints have been studied in their own right for considerations of feasibility or practicality; they are usua...

This paper describes a technique for importing automatically an external relational schema into Pegasus, a heterogeneous, multidatabase system. The Pegasus data model is a functional object model which supports specialization, object-identity, and nested aggregation. The import algorithm generates the definition of a Pegasus schema which captures the semantics of a relational schema containing ...

PURPOSE To establish the relation between AMD stage and a quantitative measure for the integrity of foveal cone photoreceptors related to the optical Stiles-Crawford effect. METHODS Fifty-six AMD eyes and 57 control eyes were included in the final analysis. AMD was graded in accordance with the International Classification System into five mutually exclusive stages. Stages 0 to 1 were labeled...

Checking the consistency of a database state generally involves the execution of integrity tests (query that returns the value true or false) on the database, which verify whether the database is satisfying its constraints or not. Many types of integrity tests have been proposed and presented in the literature. The previous works in the area of checking integrity constraints in distributed data...

The present research examined the effects of intrinsic and extrinsic goal attainment on older adults’ ego-integrity, psychological well-being, and death attitudes. Hypotheses were derived from SelfDetermination Theory (SDT; Deci & Ryan, 2000; Vansteenkiste, Ryan, & Deci, in press). Study 1 (N = 202, Mean age = 68.2 years) indicated that, after controlling for extrinsic goal attainment, intrinsi...

OBJECTIVE To investigate the association of kidney function with white matter microstructural integrity. METHODS We included 2,726 participants with a mean age of 56.6 years (45% men) from the population-based Rotterdam Study. Albumin-to-creatinine ratio, and estimated glomerular filtration rate (eGFR), using serum cystatin C (eGFRcys) and creatinine (eGFRcr), were measured to evaluate kidney...

BACKGROUND AND PURPOSE Poststroke cognitive impairment occurs frequently in young patients with ischemic stroke (18 through 50 years of age). Accumulating data suggest that stroke is associated with lower white matter integrity remote from the stroke impact area, which might explain why some patients have good long-term cognitive outcome and others do not. Given the life expectancy of decades i...