Although it has been reported that vascular endothelial growth factor (VEGF) promotes not only angiogenesis but also osteoclast and osteoblast differentiation, few reports exist regarding VEGF/VEGF receptor (VEGFR) signaling in osteoblasts, which regulate osteoclast differentiation and generate VEGF. This study examined the expression of the bone remodeling factor VEGF-A and its receptors, VEGF...

Nickel-base superalloys have become the key materials of hot-end components in the aeroengines over the past several decades. Nickelbase superalloys are easy to produce thermo-mechanical fatigue (TMF) behavior when withstanding the combined effects of high temperature, creep, oxidation, mechanical stress and thermal stress. The occurrence of TMF seriously affects the normal service for hot-end ...

Transmission of mechanical stimuli through the actin cytoskeleton has been proposed as a mechanism for rapid long-distance mechanotransduction in cells; however, a quantitative understanding of the dynamics of this transmission and the physical factors governing it remains lacking. Two key features of the actin cytoskeleton are its viscoelastic nature and the presence of prestress due to actomy...

Recent experiments have demonstrated very rapid long-distance transmission of mechanical forces within cells. Because the speed of this transmission greatly exceeds that of reaction-diffusion signaling, it has been conjectured that it occurs via the propagation of elastic waves through the actin stress fiber network. To explore the plausibility of this conjecture, we recently developed a model ...

The effect of focal mechanical stress on the localization of TRPV2 was investigated in HT1080 cells, where only mRNA for TRPV2 was detected among members of the TRPV channel family. Mechanical stress was applied by adding negative pressure using a glass pipette. When focal mechanical stress was applied, subplasma membrane Ca(2+) concentration ([Ca(2+)]s) was increased beneath the pipette, which...

Prompted by intriguing events observed in certain particle-physics searches for rare events, we study light and acoustic emission simultaneously in some inorganic scintillators subject to mechanical stress. We observe mechanoluminescence in Bi4Ge3O12, CdWO4, and ZnWO4, in various mechanical configurations at room temperature and ambient pressure. We analyze the temporal and amplitude correlatio...

We examine the surface morphological evolution of a conducting crystalline solid under the simultaneous action of an electric field and mechanical stress based on a fully nonlinear model and combining linear stability theory with self-consistent dynamical simulations. We demonstrate that electric current, through surface electromigration, can stabilize the surface morphology of the stressed sol...

Physical Factors in the Pathogenesis of Cerebral A therosclerosis • This report consists of an analysis of autopsy material from 5,031 cases. The cerebral vessels, as represented by the circle of Willis, were scored for severity and extent of atherosclerosis. The effect of physical factors on this process was considered. It is concluded from our data that LaPlace's law best explains the mechani...

Institut für Metallkunde und Metallphysik, RWTH Aachen, 52056 Aachen, Germany Carnegie Mellon University, Pittsburgh PA 15213, USA Abstract The migration of planar, symmetric tilt grain boundaries with different tilt axes was investigated. The driving force for the grain boundary migration was due to an external mechanical stress field. Low as well as high angle grain boundaries can move under ...

Loading conditions and complex geometry have led the cylinder heads to become the most challenging parts of diesel engines. One of the most important durability problems in diesel engines is due to the cracks valves bridge area. The purpose of this study is a thermo-mechanical analysis of cylinder heads of diesel engines using a two-layer viscoelasticity model. The results of the thermo-mechani...