When producing recombinant proteins, the use of Escherichia coli strain BL21(DE3) in combination with the T7-based pET-expression system is often the method of choice. In a recent study we introduced a mechanistic model describing the correlation of the specific glucose uptake rate (qs,glu) and the corresponding maximum specific lactose uptake rate (qs,lac,max) for a pET-based E. coli BL21(DE3)...

The main idea of this note is to show the most basic and purely mechanistic model of population growth, which has been used by us to create models of interspecific competition for verification of the competitive exclusion principle (1, 2). Our logical deterministic individual-based cellular automata model demonstrates a spatio-temporal mechanism of the S-shaped population growth. A classical mo...

Mechanistic explanations in biology have continually confronted the challenge that they are insufficient to account for biological phenomena. This challenge is often justified as accounts of biological mechanisms frequently fail to consider the modes of organization required to explain the phenomena of life. This, however, can be remedied by developing analyses of the modes of organization foun...

Summary. Time dynamics are often ignored in causal modelling. Clearly, causality must operate in time and we show how this corresponds to a mechanistic, or system, understanding of causality. The established counterfactual definitions of direct and indirect effects depend on an ability to manipulate the mediator which may not hold in practice, and we argue that a mechanistic view may be better....

Stereoelectroencephalography (SEEG) signals can be obtained by implanting deep intracranial electrodes. SEEG depth electrodes record brain activity from the shallow cortical layer and structures, which is not achievable through other recording techniques. Moreover, has advantage of a high signal-to-noise ratio (SNR). Therefore, it provides potential way to establish highly efficient brain-compu...