Background and Objective: The mechanism of analgesic and anxiolytic activity of resveratrol in neuropathic pain conditions remains obscure. The present study was conducted to examine whether the analgesic and anxiolytic activities of resveratrol are associated with α1- and α2-adrenoceptors of the anterior cingulate cortex (ACC), which is a key area of the cortex in the pain process, following n...

Whereas acute stress often results in analgesia, chronic stress can trigger hyperalgesia/allodynia. This influence of long-term stress on nociception is relevant to numerous painful pathologies, such as fibromyalgia (FM), characterized by diffuse muscular pain (hyperalgesia) and/or tenderness (allodynia). Hence, there is a need for pre-clinical models integrating a chronic-stress dimension to t...

Angiogenesis, the formation of new capillaries from pre-existing vessels, plays a critical role during bone regeneration and repair. In addition to an appropriate mechanical environment, sufficient supply of oxygen and nutrients is critical for bone formation. Mechano-biological models have been previously used to predict the time course of the differentiation process with the mechanical enviro...

Background Sensitive hearing in Drosophila requires the NOMPC (TRPN1) channel. is a bona fide mechano-electrical transduction (MET) channel whose amino-terminal ankyrin repeat (AR) domain consists of 29 ARs. These ARs assemble into helical structure, tether intracellularly to microtubules, and are essential for mechano-gating. Because these findings it was hypothesized that AR might function as...

Microglia, the intrinsic macrophages of the central nervous system, have previously been shown to be activated in the spinal cord in several rat mononeuropathy models. Activation of microglia and subsequent release of proinflammatory cytokines are known to play a role in inducing a behavioral hypersensitive state (hyperalgesia and allodynia) in these animals. The present study was undertaken to...

Nerve root compression produces chronic pain and altered spinal neuropeptide expression. This study utilized controlled transient loading in a rat model of painful cervical nerve root compression to investigate the dependence of mechanical allodynia on load magnitude. Injury loads (0-110mN) were applied quasistatically using a customized loading device, and load thresholds to produce maintained...

Neuropathic pain is common in clinical practice. Exploration of new drug therapeutics has always been carried out for more satisfactory effects and fewer side-effects. In the present study, we aimed to investigate effects of Tongluo Zhitong Prescription (TZP), a compounded Chinese medicine description, on neuropathic pain model of rats with chronic constriction injury (CCI). The CCI model was e...

Abstract: Background: Streptozotocin (STZ) induced neuropathy is widely used preclinical model for diabetic (DN). DN majorly resulted due to nitrosative and oxidative stress by hyperglycemia. Phenolic acids are polyphenols with free radical scavenging anti-inflammatory neuroprotectiveaction. Methods: In this study STZ (55mg/kg, i.p) was administered in male Wistar rats animals hyperglycemia (fa...