The Pharmacovigilance Centre Lareb received 621 reports of possible adverse drugs reactions on Diane-35® . Of all reports, 388 were received after media attention. Of the 309 reports of thromboembolic adverse drugs reactions, 18 cases were fatal. In 31 cases the thromboembolic adverse drugs reaction was initially not recognized as such. The analysis and the turmoil of the 'Diane affair' gave ri...

Three experiments examined the effects of perirhinal cortex lesions on rats' retrograde and anterograde memory for object-discriminations and water-maze place-memory problems. In Experiment 1, rats learned two object-discriminations - the first was learned 2 weeks before surgery and the second 24 h before surgery. Rats with perirhinal cortex lesions displayed mildly impaired retention of both o...

The responses of high-level neurons tend to be mixtures of many different types of signals. While this diversity is thought to allow for flexible neural processing, it presents a challenge for understanding how neural responses relate to task performance and to neural computation. To address these challenges, we have developed a new method to parse the responses of individual neurons into weigh...

The first direct spectroscopic evidence and characterization of triplet states in a molecular dication is reported. The 'II, ,ZU+ electronic absorption between excited states of N22+ is recorded by ion-laser coaxial beam photofragmentation spectroscopy. Over 300 rotational lines are resolved, and 13 parameters characterizing the upper and lower electronic states are determined. The results are ...

We developed a behavioral paradigm for the rat that made it possible to separate the evaluation of memory functions from the evaluation of perceptual functions. Animals were given extensive training on an automated two-choice discrimination task and then maintained their memory performance at a high level while interpolated probe trials tested visual perceptual ability. The probe trials systema...

This study evaluated the outcomes of using porous tantalum rods for the treatment of osteonecrosis of the femoral head (ONFH). We performed core decompression and inserted porous tantalum implants in 149 patients (168 consecutive hips) with ONFH. Hips had large (65), medium (64), or small (39) lesions; 63 lesions were lateral, 68 were central, and 35 were medial. Conversion to total hip arthrop...

Online three-dimensional (3D) virtual worlds are emerging technologies that offer unique learning opportunities for traditional and distributed education. One of the more popular 3D virtual worlds, Active Worlds, is currently being used as a medium for synchronous and asynchronous distance learning. This investigation presents two exploratory case studies of different, but exemplary educational...

The broadcast scheduling problem asks how a multihop network of broadcast transceivers operating on a shared medium may share the medium in such a way that communication over the entire network is possible. This can be naturally modeled as a graph coloring problem via distance-2 coloring (L(1, 1)-labeling, strict scheduling). This coloring is difficult to compute and may require a number of col...

Based on the finite-temperature field theory, we evaluate the medium effects in nucleon which can induce an asymmetry between quarks and antiquarks of the strange sea. The short-distance effects determined by the weak interaction can give rise to δm ≡ ∆ms −∆ms where ∆ms(s) is the medium-induced mass of strange quark by a few KeV at most, but the long-distance effects by strong interaction are s...

The time-dependent radiative transport equation is solved for the three-dimensional spatially uniform infinite medium which is illuminated by a point unidirectional source using a spherical harmonics transform under rotation. Apart from the numerical evaluation of a spherical Hankel transform which connects the spatial distance with the radial distance in Fourier space, the dependence on all va...