We present an interactive literature based biomedical discovery support system (BITOLA). The goal of the system is to discover new, potentially meaningful relations between a given starting concept of interest and other concepts, by mining the bibliographic database Medline. To make the system more suitable for disease candidate gene discovery and to decrease the number of candidate relations, ...

MOTIVATION A central problem in bioinformatics is how to capture information from the vast current scientific literature in a form suitable for analysis by computer. We address the special case of information on protein-protein interactions, and show that the frequencies of words in Medline abstracts can be used to determine whether or not a given paper discusses protein-protein interactions. F...

OBJECTIVE The objective of this study is to make a comparative description of the evolution and distribution of international research into pharmacoepidemiology, using three bibliographic databases, in order to select the most appropriate for future bibliometric studies. METHODS Bibliographic searches were performed using the following databases: Medline (1966-99), IPA (1970-99) and SCI (1990...

Biopsy is a useful technique for definitive diagnosis of abnormal oral conditions and it must be performed carefully since any error may result in histopathologic misidentification of the lesion. Present study evaluated the most relevant literatures published between 1982 and 2012 in order to review existed guidelines of correct biopsy performance using scientific database sources such as PubMe...

This paper gives an overview of the Caderige project. This project involves teams from different areas (biology, machine learning, natural language processing) in order to develop highlevel analysis tools for extracting structured information from biological bibliographical databases, especially Medline. The paper gives an overview of the approach and compares it to the state of the art.

Clinical practice guidelines are one of the main resources for communicating evidence-based practice to health professionals. During guideline development, questions that express a knowledge gap are answered by finding relevant citations in MEDLINE and other biomedical databases. Determining citation relevance involves extensive manual review. We propose an automated method for finding relevant...

Background: The World Health Organization suggested that frailty is a critical indicator influencing successful aging. Previous studies have indicated a high correlation between frailty and bone fracture in older adults. However, few studies have investigated the correlation between the various stages of frailty with bone fracture risk. Purpose: This study investigated the correlation between f...

BACKGROUND Medline is one of the most important databases in the biomedical field. One of the most important hosts for Medline is Elton B. Stephens CO. (EBSCO), which has presented different search methods that can be used based on the needs of the users. Visual search and MeSH-controlled search methods are among the most common methods. The goal of this research was to compare the precision of...

The vast number of published medical documents is considered a vital source for relationship discovery. This paper presents a statistical unsupervised system, called BioNoculars, for extracting protein-protein interactions from biomedical text. BioNoculars uses graph-based mutual reinforcement to make use of redundancy in data to construct extraction patterns in a domain independent fashion. Th...