نتایج جستجو برای: medulloepithelioma
تعداد نتایج: 103 فیلتر نتایج به سال:
A 98-year-old asymptomatic white female was referred with the incidental finding of a suspicious right iris mass. Medical history included treated hypertension and hypothyroidism. On examination, visual acuity was 20/60 in the right eye and 20/40 in the left eye. The left eye was structurally normal. In the right eye there was erosion of the iris root at the 1 o'clock position (Fig. 1). Through...
PURPOSE To study the differential expression of microRNA (miRNA) profiles between intraocular medulloepithelioma (ME) and normal control tissue (CT). MATERIAL AND METHODS Total RNA was extracted from formalin fixed paraffin embedded (FFPE) intraocular ME (n=7) and from age matched ciliary body controls (n=8). The clinical history and phenotype was recorded. MiRNA profiles were determined usin...
PURPOSE Although gliomas predominate among central nervous system (CNS) neoplasms in adulthood, embryonal tumors are the most common malignant brain tumors in children. Despite novel treatment approaches, including improved radiotherapy and high-dose chemotherapy, survival rates remain unsatisfactory. The timely diagnosis of residual or recurrent embryonal CNS tumors and thus the earliest possi...
s of the 51st Workshop for Pediatric Research 51st Workshop for Pediatric Research Göttingen, Germany 16-17 April 2015 This supplement has not been sponsored. Meeting abstracts Introduction Genome-wide profiling and next-generation based sequencing studies have dramatically improved our understanding of embryonal brain tumor (EBT) biology in the recent years. However, the vast majority of these...
Amplification of the C19MC oncogenic miRNA cluster and high LIN28 expression has been linked to a distinctly aggressive group of cerebral CNS-PNETs (group 1 CNS-PNETs) arising in young children. In this study, we sought to evaluate the diagnostic specificity of C19MC and LIN28, and the clinical and biological spectra of C19MC amplified and/or LIN28+ CNS-PNETs. We interrogated 450 pediatric brai...
BACKGROUND Constitutional DICER1 mutations were recently reported to cause familial pleuropulmonary blastoma (PPB). AIM To investigate the contribution and phenotypic spectrum of constitutional and somatic DICER1 mutations to cancer. METHODS AND RESULTS The authors sequenced DICER1 in constitutional DNA from 823 unrelated patients with a variety of tumours and in 781 cancer cell lines. Cons...
The coral derived hydroxyapatite sphere is a popular, integrated orbital implant designed to provide improved motility of the ocular prosthesis following enucleation. Although the implant has rapidly become widely used by ophthalmologists, little information is available regarding the problems of this technique in a large series of cases. Experience with 250 consecutive cases of hydroxyapatite ...
Pujari A, Swamy DR. BMJ Case Rep 2017. doi:10.1136/bcr-2017-222126 Description A 26-year-old male patient presented for routine ocular evaluation; visual acuity was 20/20 in each eye with +0.75 dioptre sphere. Bilateral anterior segment examination showed a clear cornea and a normal central anterior chamber depth. In the right eye towards the periphery on temporal aspect, anterior surface of th...
Making the correct diagnosis of an iris–ciliary body tumor can be challenging. A 35-year-old woman sought care because of a growing amelanotic lesion that destroyed the iris root and produced a large ciliary body mass. She had a history of systemic lupus erythematosus. The tumor was completely removed with an iridocyclectomy, which revealed that the plasma cells had been producing a large amoun...
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