Giant congenital melanocytic nevus is usually defined as a melanocytic lesion present at birth that will reach a diameter ≥ 20 cm in adulthood. Its incidence is estimated in <1:20,000 newborns. Despite its rarity, this lesion is important because it may associate with severe complications such as malignant melanoma, affect the central nervous system (neurocutaneous melanosis), and have major ps...

OBJECTIVE To compare dermoscopic features of melanocytic nevi with those of early melanomas that were not excised initially because of their uncharacteristic clinical and dermoscopic appearance. DESIGN Retrospective study of the baseline images of 325 melanocytic skin lesions that were observed by digital dermoscopy and finally excised because of changes over time. SETTING A dermatologic cl...

background: one of the most common cancers is skin cancer worldwide. since incidence and cost of treatment of the cancer are increasing, it is necessary to further investigate to prevent and control this disease. this study aimed to determine skin cancer trend and epidemiology in iran. methods: this study was done based on existing data. data used in this study were obtained from a national reg...

METHODS: 60 patients who had non-melanocytic skin cancer on the only nasal tip were included in this study. There was no previous history of nasal surgery, allergic rhinitis, concha hypertrophy and other breathing problems in any patients. Six patients were treated with forehead flap, ten patients nasolabial island flap, twenty patients bilobe flap that based on inferior, 24 patients bilobe fla...

We investigated the role of molecular and biological aging in pathophysiology cutaneous melanoma melanocytic nevi. Epigenetic age dysregulation (deviation epigenetic from chronological age) is associated with greater risk all-cause mortality complex diseases including cancer. Using a cross-sectional approach, we calculated using methylCIPHER R package for eight clocks that predict (Horvath, Hor...

Introduction. Basal cell carcinoma is the most common type of non-melanocytic malignant tumors skin. The main treatment methods for this pathology are local such as surgery and radiation. In rare cases, basal can become locally advanced / or metastatic. Aim. To demonstrate possibility reconstructive large defects after removal face describe a case metastasis into regional lymph nodes. Clinical ...

BACKGROUND Melanocytic nevi are frequently found on acral volar skin. Differentiation between nevi and melanoma is essential and sometimes difficult, although dermoscopy has enabled a more specific diagnosis of pigmented lesions. Dermoscopic patterns of lesions on acral volar skin have mostly been described in European and Asian populations. The Latin American population is heterogeneous, and p...

BACKGROUND Digital computer analysis of dermatoscopical images has been reported to facilitate the differential diagnosis of pigmented skin lesions in recent years. OBJECTIVE The aim of our study was to perform digital computer analysis of a set of different melanocytic lesions and compare the objective results. METHODS The set of 260 melanocytic lesions (150 excised difficult cases (46 mel...

In this paper, we propose a novel approach to discriminate malignant melanomas and benign atypical nevi, since both types of melanocytic skin lesions have very similar characteristics. Recent studies involving the non-invasive diagnosis of melanoma indicate that the concentrations of the two main classes of melanin present in the human skin, eumelanin and pheomelanin, can potentially be used in...