olanzapine is the frequently prescribed drug in children and adolescents with bipolar disorder, but unfortunately it has metabolic side-effects. on the other hand, in a number of melatonin studies on sleep cycle, regulation of metabolic abnormalities has been reported. therefore, we aimed to study effects of melatonin in reducing metabolic side-effects of olanzapine in 11-17 year-old patients w...

Purpose. The main objective of the study was to create a mathematical model that describes the melatonin circadian secretion and, then the functionality of the model was tested by a comparison of the melatonin secretions in children with and without epilepsy. Material and Methods. The patients were divided into the epilepsy group (EG, n = 52) and the comparison group (CG, n = 30). The melatonin...

Lower melatonin level, melatonin receptor gene variations, and atenolol treatment are associated with glucose dysregulation. We investigated whether atenolol-related glucose and melatonin changes are correlated, and whether single nucleotide polymorphisms (SNPs) in melatonin candidate genes contribute to interindividual variation in glucose change. Hypertensive Caucasians (n = 232) from the Pha...

Abstract Background As one of the most common surgeries performed in veterinary medicine, ovariohysterectomy (OHE) can induce oxidative stress dogs. The antioxidant properties melatonin have been confirmed various studies. This study aimed to investigate effects administration on dogs before and after OHE. In this study, 25 mature female intact were selected randomly divided into five equal gro...

The interaction of immunological system, thyroid and pineal gland was studied in 5-week old males of Gallus domesticus. Several morphometrical parameters in pineal and thyroid glands were measured after bird immunization with human red blood cells and/or treatment with melatonin or seduxen, melatonin receptor blocker. The peak of the thyroid activity was found on Day 7 after immunization. The i...

Melatonin plays several important physiological functions in mammals, such as immune enhancement and regulation of dark-light signal transduction. Melatonin is also known to be an endogenous free radical scavenger and an efficient antioxidant. It detoxifies a variety of free radicals and reactive oxygen intermediates, including the hydroxyl radical, singlet oxygen and nitric oxide. These radica...

The pineal hormone, melatonin, is uniquely defined by its role as hormonal time, but the processes whereby cells extract temporal information from the melatonin signal are not understood. Melatonin receptors are expressed in the pars tuberalis (PT) and, during fetal and perinatal life, in the pars distalis (PD). Functional studies suggest that the PT mediates the seasonal effects of melatonin o...

OBJECTIVES To evaluated the effects of melatonin on early embryo competence and the expression rate of the primary implantation receptors (ErbB1 and ErbB4). MATERIALS AND METHODS Two-cell mouse embryos were cultured in 3 groups: simple media, melatonin-treated (10-9 M melatonin) and Luzindole-treated (10-9 M luzindole). Then, the rate of ErbB1 and ErbB4 gene and protein expression, the level ...

Objective: To correlate serum levels of melatonin and cortisol in sickle cell anemia (SCA) with age, age at diagnosis, sex, anthropometry, vaso-occlusive crisis (VOC) and current treatment. Methods: Twenty nine patients and 29 controls were recruited into this study. Melatonin and Cortisol assays were performed using commercially available ELISA kit. Statistical analysis was done to assess the ...