Photocatalytic ceramic membranes have attracted considerable attention for industrial wastewater treatment. However, morphological control of the membrane surface to improve its photocatalytic reactivity for the degradation of organic pollutants remains a challenge. Herein, we report a new nanostructured TiO2/Al2O3 composite ceramic membrane prepared from a poly(oxyethylene methacrylate) (POEM)...

Copper alloy surfaces are passive antimicrobial sanitizing agents that kill bacteria, fungi, and some viruses. Studies of the mechanism of contact killing in Escherichia coli implicate the membrane as the target, yet the specific component and underlying biochemistry remain unknown. This study explores the hypothesis that nonenzymatic peroxidation of membrane phospholipids is responsible for co...

Tight control of membrane protein homeostasis by selective degradation is crucial for proper cell signaling and multicellular organismal development. Membrane proteins destined for degradation, such as misfolded proteins or activated receptors, are usually ubiquitinated and sorted into the intraluminal vesicles (ILVs) of prevacuolar compartments/multivesicular bodies (PVCs/MVBs), which then fus...

pared with that of normal liver. However, the rate of degradation of membrane protein in the 7800 hepatoma was more rapid than that in its host liver, while the proteins of the reticular membranes of the Morris 9618A hepatoma decayed at a slower rate than did those of its host liver. Despite the varied decay rates, the yields of microsomal membrane protein from the hepatomas were diminished in ...

BAP31 is an endoplasmic reticulum protein-sorting factor that associates with newly synthesized integral membrane proteins and controls their fate (i.e., egress, retention, survival, or degradation). BAP31 is itself an integral membrane protein and a constituent of several large protein complexes. Here, we show that a part of the BAP31 population interacts with two components of the Sec61 prepr...

Little is known about quality control of proteins that aberrantly or persistently engage the endoplasmic reticulum (ER)-localized translocon en route to membrane localization or the secretory pathway. Hrd1 and Doa10, the primary ubiquitin ligases that function in ER-associated degradation (ERAD) in yeast, target distinct subsets of misfolded or otherwise abnormal proteins based primarily on deg...

This paper reviewed over 100 articles on the subject of the mechanism of catalyst layer (CL) degradation and the effect of various contaminations in the polymer electrolyte membrane fuel cell (PEMFC). Also the recovery of PEMFC via different types of methods, the causes and fundamental mechanisms of cell degradation and their influence on long- term performance of PEM fuel cell were discussed i...

The protein known as p97 or VCP in mammals and Cdc48 in yeast is a versatile ATPase complex involved in several biological functions including membrane fusion, protein folding, and activation of membrane-bound transcription factors. In addition, p97 plays a central role in degradation of misfolded secretory proteins via the ER-associated degradation pathway. This functional diversity of p97 dep...

The modification of cytosolic proteins with polyubiquitin chains targets them for recognition and degradation by the multisubunit proteolytic particle, the 26S proteasome. Membrane proteins are also substrates for ubiquitination. Integral membrane proteins of the endoplasmic reticulum are ubiquitinated and destroyed by the proteasome. However, it has been shown recently that the ubiquitination ...

We have analyzed the functions of two vacuolar t-SNAREs, Vam3p and Vam7p, in peroxisome degradation in the methylotrophic yeast Hansenula polymorpha. A Hp-vam7 mutant was strongly affected in peroxisome degradation by selective macropexophagy as well as non-selective microautophagy. Deletion of Hp-Vam3p function had only a minor effect on peroxisome degradation processes. Both proteins were loc...