نتایج جستجو برای: meningiomas
تعداد نتایج: 3382 فیلتر نتایج به سال:
Research over the last decade recognized the importance of novel molecular pathways in pathogenesis of intracranial meningiomas. In this review, we focus on human brain tumours meningiomas and the involvement of Wnt signalling pathway genes and proteins in this common brain tumour, describing their known functional effects. Meningiomas originate from the meningeal layers of the brain and the sp...
Meningiomas are among the most common adult brain tumors. Although the optimal management of meningiomas would provide complete elimination of the lesion, this cannot always be accomplished safely through resection. Therefore, other therapeutic modalities, such as stereotactic radiosurgery (as primary or adjunctive therapy), have emerged. In the current review, we have provided an overview of t...
BACKGROUND Tissue invasion or tissue infiltration are clinical behaviors of a poor-prognosis subset of meningiomas. We carried out proteomic analyses of tissue extracts to discover new markers to accurately distinguish between infiltrative and noninfiltrative meningiomas. METHODOLOGY/PRINCIPAL FINDINGS Protein lysates of 64 different tissue samples (including two brain-invasive and 32 infiltr...
CONTEXT Lymphangioleiomyomatosis (LAM), a cystic lung disease associated with progressive respiratory failure, is found predominantly in women of childbearing age and therefore has been treated with progesterone and other hormonal agents. However, meningiomas have progesterone receptors, and progesterone is believed to be a mitogen for meningioma cells in culture. Since 30% to 40% of patients w...
Background Recent studies have reported mutations in the telomerase reverse transcriptase promoter (TERTp) in meningiomas. We sought to determine the frequency, clonality and clinical significance of telomere gene alterations in a cohort of patients with progressive/higher-grade meningiomas. Methods We characterized 64 temporally- and regionally-distinct specimens from 26 WHO grade III mening...
BACKGROUND AND PURPOSE Atypical and malignant meningiomas are uncommon tumors with aggressive behavior and higher mortality, morbidity, and recurrence compared with benign tumors. We investigated the utility of diffusion-weighted (DW) MR imaging to differentiate atypical/malignant from benign meningiomas and to detect histologic dedifferentiation to higher tumor grade. MATERIALS AND METHODS W...
Learning Objectives: After reading this article, the participant should be able to: 1. Recall the incidence and differential diagnosis offoramen magnum meningiomas. 2. Describe the clinical presentation and the pre-operative evaluation ofpatients with foramen magnum meningiomas, including the radiologic features and the different types offoramen magnum meningiomas. 3. Explain the pre-operative ...
Primary extradural meningiomas presenting as scalp swelling is uncommon. Their diagnosis by fine needle aspiration is rare as majority of the lesions are hyperostotic. Primary intraosseus meningiomas involving the skull constitute only about 2% of meningiomas and are often mistaken for other primary or secondary bone tumors. The authors report a case of primary calvarial meningioma involving th...
Meningiomas are the second most common brain tumors in adults, and meningiomas exhibit a tendency to invade adjacent structures. Compared with high-grade gliomas, little is known about the molecular changes that potentially underlie the invasive behavior of meningiomas. In this study, we examined the expression and function of the membrane alanyl-aminopeptidase [mAAP, aminopeptidase N (APN), CD...
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