The aim of this study was to investigate the potential of curcumin oral supplementation (50 and 100 mg/Kg/day, for 30 days) in circumventing menopause-associated oxidative stress and lipid profile dysfunctions in a rat ovariectomy (OVX) model. Female Wistar rats were operated and randomly divided into either sham-operated or OVX groups. Sham-operated group (n = 8) and one OVX group (n = 11) wer...

Menopause causes cognitive and memory dysfunction due to impaired neuronal plasticity in the hippocampus. Sirtuin-1 (SIRT1) downregulation in the hippocampus is implicated in the underlying molecular mechanism. Edible bird's nest (EBN) is traditionally used to improve general wellbeing, and in this study, we evaluated its effects on SIRT1 expression in the hippocampus and implications on ovarie...

OBJECTIVE Motivated by inconsistent literature, we evaluated the association between incident pancreatic cancer and reproductive characteristics. DESIGN The Iowa Women's Health Study is a large prospective population-based cohort followed from 1986 to 2003. Reproductive information was self-reported. PARTICIPANTS The study population comprised 37,459 women aged 55-69 years at baseline. Over...

BACKGROUND Although the timing of menarche and menopause may be associated with cardiovascular disease (CVD), the entire reproductive life span has not been considered comprehensively as risk for CVD. We investigate the associations of reproductive life span duration and ages at menarche and menopause, induced by natural means or surgical bilateral oophorectomy, with incident CVD in women. ME...

INTRODUCTION Although increasing age is a primary determinant of reduced sexual function in older women, hormonal changes may be significant contributors to female (and couples') sexual dysfunction. AIM To analyze the most relevant biological, psychosexual, and/or contextual factors that influence changes in women's sexuality during and after menopause. METHODS A Postmenopausal FSD Roundtab...

This article performed a model of osteoporosis rats using the method ovariectomy and observed efficacy Tianchang Capsule on treatment rats. Comparing effect with positive drug to explore mechanism in postmenopausal osteoporosis. Female SD were randomly assigned 6 groups (10 each group): control (sham-treated), OVX (by ovariectomy), OVX+AL ovariectomy, received alendronate sodium), OVX+LTC low d...

In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: a r t i c l e i n f o a b s t r a c t Reproductive hormones have been demonstrated to modulate both gap and tight junction p...

STUDY QUESTION Is the age at menopause in a cohort of childhood cancer survivors earlier and what are the risk factors associated with earlier age at menopause? SUMMARY ANSWER Menopause occurred at a median age of 44 years in this cohort which is earlier than in the general population, but premature menopause was uncommon. Main risk factors for non-surgical menopause were exposure to and dose...

deficiency following menopause is by far the most common cause of age-related bone loss. Postmenopausal osteoporosis (POP) has become a major problem with significant morbidity and mortality. Bone loss induced by ovariectomy in rats has been widely used as a model of POP and has been validated as a clinically relevant model of this condition in human. Peripheral quantitative computed tomography...