OBJECTIVES Mesenchymal stem cells (MSC) can be isolated from adult tissues such as adipose tissue and other sources. Among these sources, adipose tissue (because of easy access) and placenta (due to its immunomodulatory properties, in addition to other useful properties), have attracted more attention in terms of research. The isolation and comparison of MSC from these two sources provides a pr...

Main Text(Cell Metabolism 33, 283–299.e1–e9; February 2, 2021)Figure 3G. Platelet-Derived Mitochondria Stimulate Pro-angiogenic Properties of MSCs (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 5C. Angiogenesis via Activation De Novo Fatty Acid Synthesis in (corrected)View 7F. Citrate Restores the Effects Incubated with ROT/AA-Treated Platelets (PPT) (Cell 20...

BACKGROUND SK Hep-1 cells (SK cells) derived from a patient with liver adenocarcinoma have been considered a human hepatoma cell line with mesenchymal origin characteristics, however, SK cells do not express liver genes and exhibit liver function, thus, we hypothesized whether mesenchymal cells might contribute to human liver primary cancers. Here, we characterized SK cells and its tumourigenic...

A growing number of autoimmune diseases, allergies, and atopic conditions in recent years are calling for the development innovative therapies, such as those using stem cells with immunoregulatory activity. Because few often conflicting results scientific literature, it is still uncertain whether mesenchymal (MSC) could be a useful therapeutic strategy targeting B lymphocytes helpful treating a...

Cell-Free Therapies hBMMSC-apoVs can promote mesenchymal stem cell (MSC) osteogenesis and inhibit osteoclast formation in vitro vivo. The mechanisms include the release of miR1324, which inhibits expression target gene SNX14, thereby activating SMAD1/5 pathway cells. In article number 2205813, Xiao Zhang, Yunsong Liu, co-workers suggest a therapeutic strategy for treatment bone loss, including ...

stem cell research has obtained much prominence in recent years for its therapeutic potential in dealing with serious diseases, many of which are essentially incurable by routine therapies. mesenchymal stem cells with pluripotency and immunomodulatory properties are suitable candidates for tissue engineering and regenerative medicine. today, nanofibrous scaffolds are widely used in tissue engin...

purpose : our aim was to isolate mesenchymal stem cells (mscs) from mouse umbilical cord and culture them with vitreous body to investigate their capacity to differentiate into lens fiber cells, crystallins are expressed. methods : wharton's jelly is the appropriate source of mscs. after isolation, the cells were cultured and alkaline phosphatase detection kit was used for staining undiffe...

background: mesenchymal stem cells (mscs) are undifferentiated cells that can differentiate and divide to other cell types. transplantation of these cells to the different organs is used for curing various diseases. objective: the aim of this research was whether mscs transplantation could treat the sterile testes. materials and methods: in this experimental study, donor mscs were isolated from...

Objective(s): Cord blood (CB) is known as a valuable source of hematopoietic stem cells (HSC). Identifying strategies that enhance expansion and maintain engraftment and homing capacity of HSCs can improve transplant efficiency. In this study, we examined different culture conditions on ex vivo expansion and homing capacity of CB-HSCs. Materials and Methods: In this study, 4-5 different units o...