Spinal cord injury (SCI) is a neurologic disorder that have a significant impact on quality of life, life expectancy, and economic burden. SCI leads to irreversible neuronal loss and ultimately leads to paralysis. Mesenchymal stem cells (MSCs) are a promising source for cellular therapy because they have possessed the capacity of self-renewal and differentiation to several distinct mesenchymal ...

Osteosarcoma refers to a bone tumor and the term was introduced by John Abernathy in 1804 referring fleshy growth [1]. In 2009, Ottaviane G. et al reported that osteosarcoma is an aggressive malignancy arises from primitive transformed cells of mesenchymal origin produces malignant osteoid, which are most common representation primary cancer [2,3].

Rhabdomyosarcoma is the most frequent mesenchymal tumor in children, composed of cells with histopathological characteristics striated muscle at different stages embryogenesis. The orbital location accounts for about 10% cases. Its prognosis has improved thanks to progress chemotherapy and new radiotherapy techniques.The aim our study report clinical therapeutic rhabdomyosarcomas orbit present ...

Malignant melanoma is the most lethal form of skin cancer. Y-box binding protein 1 (YB-1) plays a prominent role in mediating metastatic behavior by promoting epithelial-to-mesenchymal transition (EMT). Migratory cells exhibit two major migration modes: elongated mesenchymal or rounded amoeboid. Using A375 cell line and YB-1 knock-out model, we aimed to elucidate biochemical biomechanical chang...

background: primary leiomyosarcoma (lms) of the breast is a very rare neoplasm of the breast arising from the mesenchymal tissue. the clinical presentation of this entity simulates other benign and malignant lesions of mesenchymal tissue of the breast. case presentation: case 1: a 40-year-old female presented with a right-sided breast lump, which was suspected to be a malignant spindle cell tum...

Cancer invasion and the ability of malignant tumor cells for directed migration and metastasis have remained a focus of research for many years. Numerous studies have confirmed the existence of two main patterns of cancer cell invasion: collective cell migration and individual cell migration, by which tumor cells overcome barriers of the extracellular matrix and spread into surrounding tissues....

Malignant phyllodes tumor is usually diagnosed by the presence of benign duct-like epithelium and malignant mesenchymal tissue. In addition to the usual fibrosarcomatous features, the mesenchymal component may show areas resembling osteogenic sarcoma, chondrosarcoma, liposarcoma, leiomyosarcoma, rhabdomyosarcoma, malignant mesenchymoma, and, very rarely, malignant fibrous histiocytoma. We prese...

Exosomes derived from mesenchymal stem cells (MSC-Exos) are nano-sized extracellular vesicles enriched with bioactive molecules, such as microRNAs, enzymes, cytokines, chemokines, immunomodulatory, trophic, and growth factors. These molecules regulate the survival, phenotype, function of malignant tumor-infiltrated immune cells. Due to their nano-size bilayer lipid envelope, MSC-Exos can easily...

Tumor‑stroma interactions serve a crucial role in the development of colorectal cancer (CRC), which secreted protein acidic and rich cysteine (SPARC) has been implicated. Due to between stromal cells [mesenchymal stem (MSCs)], SPARC gene expression is markedly upregulated CRC cells. The present study investigated its potential as biomarker. Specifically, examined association clinicopathological...