Background: Breast conserving surgery (BCS) followed by radiotherapy (RT) has been widely accepted as the standard treatment in early stages of invasive breast cancer. The standard technique of RT includes whole breast irradiation (WBI). Additional tumor bed boost irradiation has also an important role in the local tumor control. But there are various controversial delivery methods. The aim of ...

Objective: In this study, we aimed to determine the independent predictive parameters of overall survival (OS) ofpatients with inoperable pancreatic ductal adenocarcinoma (PDAC) and investigate whether these parameterscan be used as potential biomarkers shape precision medicine practices for PDAC patients.Material Methods: The clinical pathological data patients who were diagnosed inoperablepan...

BACKGROUND The purpose of this study was to determine whether pretreatment 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) volumetric parameters add more prognostic information to p16-positive oropharyngeal squamous cell carcinoma (SCC). METHODS We retrospectively analyzed 86 patients with p16-positive oropharyngeal SCC who underwent surgery and postoperative radiotherapy (RT) o...

Cancer cells display heterogeneous genetic characteristics, depending on the tumor dynamic microenvironment. Abnormal tumor vasculature and poor tissue oxygenation generate a fraction of hypoxic tumor cells that have selective advantages in metastasis and invasion and often resist chemo- and radiation therapies. The genetic alterations acquired by tumors modify their biochemical pathways, which...

Cancer treatment is still of the greatest challenges that health care providers and patients are facing. One of the unsolved problems in cancer treatment is cells’ reaction to metabolic stress caused by harsh nutritional conditions around tumor. In order to be able to treat this disease properly, it is important to understand the true nature of the disease. In fact, the cells inside the central...

In this study, we aimed to evaluate the prognostic significance of adipose tissue distribution and metabolic activity in PET/CT predict survival patients with metastatic colorectal cancer (mCRC). The volume, density (HU), FDG uptake (standardized value (SUV)) visceral (VAT) subcutaneous (SAT) maximum tumor were measured. Subcutaneous volume-to-density ratio (SAT ratio) was calculated. median OS...