Myocardial remodeling is an adaptive response of the myocardium to several forms of stress culminating in cardiac fibrosis, left ventricular dilation, and loss of contractility. The remodeling processes of the extracellular matrix are controlled by matrix metalloproteinases, which are in turn regulated by growth factors and inflammatory cytokines. The inflammatory transcription factor nuclear f...

It is not fully elucidated whether the restoring of normal glucose metabolism after successful simultaneous pancreas-kidney transplantation (SPK) improves vascular wall morphology and function in type 1 diabetic (T1D) patients. Therefore, we compared arterial stiffness, assessed by pulse wave velocity (PWV), carotid intima-media thickness (IMT), biomarkers calcification T1D patients SPK or kidn...

Submit Manuscript | http://medcraveonline.com Abbreviations: BBB: Blood-Brain Barrier; CCA: Common Carotid Artery; CIMT: Carotid Intima-Media Thickness; COPD: Chronic Obstructive Pulmonary Disease; FEV1: Forced Expiratory Volume in 1 Second; LDL: Low Density Lipoprotein; MMPS: Matrix Metalloproteinases; SCORE Scale: Scale Of Systematic Coronary Risk Evaluation; TIMPs: Tissue Inhibitors of Matri...

Submit Manuscript | http://medcraveonline.com Abbreviations: BBB: Blood-Brain Barrier; CCA: Common Carotid Artery; CIMT: Carotid Intima-Media Thickness; COPD: Chronic Obstructive Pulmonary Disease; FEV1: Forced Expiratory Volume in 1 Second; LDL: Low Density Lipoprotein; MMPS: Matrix Metalloproteinases; SCORE Scale: Scale Of Systematic Coronary Risk Evaluation; TIMPs: Tissue Inhibitors of Matri...

Submit Manuscript | http://medcraveonline.com Abbreviations: BBB: Blood-Brain Barrier; CCA: Common Carotid Artery; CIMT: Carotid Intima-Media Thickness; COPD: Chronic Obstructive Pulmonary Disease; FEV1: Forced Expiratory Volume in 1 Second; LDL: Low Density Lipoprotein; MMPS: Matrix Metalloproteinases; SCORE Scale: Scale Of Systematic Coronary Risk Evaluation; TIMPs: Tissue Inhibitors of Matri...

Metalloproteinases have been implicated as important factors mediating the tissue migration of a variety of normal and transformed cells. The conditioned medium (CM) of fetal human astrocytes and five glioma cell lines did not degrade azocoll in suspension, but several proteolytic activities, inhibitable by 1,10-phenanthroline, were detected on sodium dodecyl sulfate-polyacrylamide gels contain...

This paper aims to describe the physiological basis of the blood-brain barrier components and its properties. Additionally, the particular effects of metalloproteinases and their control over the extracellular matrix and its relationship with blood-brain barrier dysfunction are discussed. Finally, the role of metalloproteinases on changes in the central nervous system in critically ill patients...