Morus alba leaf methanolic extract and its fractions (chloroform, butanol, and aqueous fractions) were found to inhibit NO production in LPS-activated RAW264.7 macrophages without an appreciable cytotoxic effect at concentration from 4 to 100 microg/ml. LPS-induced PGE2 production was significantly reduced only by butanol fraction. In addition, M. alba leaf extract and its fractions significant...

A study of the chemical composition essential oil obtained from aerial parts Salvia glutinosa L., growing in Georgia, was carried out. The percentage dominant components determined by integration, component are caryophyllene oxide (11.43 %), spathulenol (5.93 humulene (4.5 %). From terpene compounds oxygenated sesquiterpenes dominants. content phenolic  using Folin-Ciocalteu reagent aqueou...

This study aimed to determine biological activity and phytochemical study of Scutellaria platystegia (family Labiatae). Methanolic (MeOH) extract of aerial parts of S. platystegia and SPE fractions of methanolic extract (specially 20% and 40% methanolic fractions), growing in East-Azarbaijan province of Iran were found to have radical scavenging activity by DPPH (2, 2-diphenyl -1- pycryl hydraz...

BACKGROUND This study was aimed to evaluate antioxidant and α-glucosidase inhibitory activity, with a subsequent analysis of total phenolic and total flavonoid content of methanol extract and its derived fractions from Clinacanthus nutans accompanied by comprehensive phytochemical profiling. METHODS Liquid-liquid partition chromatography was used to separate methanolic extract to get hexane, ...

To investigate the antiproliferative / cytotoxicity effect of methanolic fruit extract of Cucurbita digitata on human hepatocellular carcinoma HepG2 cell line. Cytotoxicity tests on HepG2 liver cancer cell lines were performed by Caspase assay, Flow cytometry and DNA fragmentation assays. Cell proliferations measured by Caspase assay exhibited significant inhibition of cell growth with an incre...

To increase the knowledge about the biological properties of tomatoes, the antioxidant and antiproliferative activities of extracts of nine cultivars of Lycopersicon esculentum, as well as their chemical composition, were studied. The highest antioxidant capacity has been revealed in San Marzano Cirio 3 and Pomodoro Giallo cultivars, both in hydrophilic and lipophilic fractions, while San Marza...

Five phenolic glycosides, clerodenoside A (1), seguinoside K (2), cistanoside D (3), verbascoside (4), and isoverbacoside (5) were isolated from the ethyl acetate soluble fraction of methanolic extract Clerodendrum inerme stems. Their structures determined by spectroscopic analysis comparison spectral data with those reported in literature. Compound 3 was this plant for first time.

A new phlorotannin, named eckstolonol (1), was isolated from the EtOAc soluble fraction of the methanolic extract of the brown alga, Ecklonia stolonifera OKAMURA, along with three known phlorotannins, eckol (2), phlorofucofuroeckol A (3), and dieckol (4). The structure of eckstolonol was identified as 5,8,13,14-tetraoxa-pentaphene-1,3,6,9,11-pentaol on the basis of spectroscopic evidence. The n...

The anti-plasmodial activity of Ailanthus excelsa stem bark was investigated. The methanolic extract inhibited in vitro growth of chloroquine-sensitive (D10) and resistant strains (W2) of Plasmodium falciparum (IC50 4.6 and 2.8 microg/ml, respectively). The effect was retained in the chloroform fraction (3.1 and 2.1 microg/ml, respectively). The anti-plasmodial activity could be ascribed to the...

Extracts obtained using methanol and dichloromethane from 57 species of wood damaging fungi were investigated for their ability to inhibit HIV-1 reverse transcriptase activity in vitro using a non-radioactive assay. Sixty-three samples were tested all together; some species were represented more than one isolate. Thirteen methanolic extracts exhibited more than 40% inhibition and two among them...