To the contrary, the information presented by Knobeloch et al. (1) support my conclusions (2). Knobeloch et al. (1) described two purported cases of infantile methemoglobinemia in their paper. The diagnosis of methemoglobinemia in case 1, however, is completely speculative: a doctor did not examine the infant, and blood methemoglobin concentrations were not measured during the observed anoxia. ...

background: the aim of present work was to evaluate the drinking water quality from various regions including both urban and rural areas of hamadan province, western iran. methods: in this cross-sectional descriptive study, the samples were collected for a periods of 12 months between january 25, 2014 and january 25, 2015 from frequently used household taps as well as from municipal and communa...

Prilocaine and lidocaine are classified as amide-type local anesthetics for which serious adverse effects include methemoglobinemia. Although the hydrolyzed metabolites of prilocaine (o-toluidine) and lidocaine (2,6-xylidine) have been suspected to induce methemoglobinemia, the metabolic enzymes that are involved remain uncharacterized. In the present study, we aimed to identify the human enzym...