BACKGROUND The JAK/STAT pathway transduces signals from multiple cytokines and controls haematopoiesis, immunity and inflammation. In addition, pathological activation is seen in multiple malignancies including the myeloproliferative neoplasms (MPNs). Given this, drug development efforts have targeted the pathway with JAK inhibitors such as ruxolitinib. Although effective, high costs and side e...

BACKGROUND Osteosarcoma is the most prevalent primary malignant bone tumor, but treatment is difficult and prognosis remains poor. Recently, large-dose chemotherapy has been shown to improve outcome but this approach can cause many side effects. Minimizing the dose of chemotherapeutic drugs and optimizing their curative effects is a current goal in the management of osteosarcoma patients. MET...

background : this study assesses the effect of oral cryotherapy on the incidence and severity of chemotherapy-induced oral mucositis in combined chemotherapy regimens. methods : this was a randomized controlled trial that enrolled 80 cancer patients. we evaluated the primary oral status of all patients prior to chemotherapy. patients were divided into two groups, experimental and control. the e...

BACKGROUND Cyclophosphamide is one of the most commonly used chemotherapy drugs worldwide. Data concerning environmental contamination and biological exposure of pharmacy personnel to this and other chemotherapy drugs are limited. OBJECTIVES To determine whether pharmacy personnel involved in preparing and checking cyclophosphamide doses were more likely to have detectable levels of this drug...

Combination chemotherapy with cyclophosphamide, methotrexate and fluorouracil (CMF) was compared with cyclophosphamide, adriamycin and fluorouracil (CAF) as adjuvant to modified radical mastectomy in primary operable breast cancer with positive axillary lymph nodes. After 18 months of study, treatment failure occurred in 10% patients in each group. The new clinical manifestations occurred local...

Fifty-six patients with untreated small cell carcinoma of the bronchus were treated with three courses of chemotherapy (cyclophosphamide, vincristine, and procarbazine and methotrexate) and assessed for response. Thirty-one patients (55.4%) were classified as responders; they were given a course of radiotherapy and were then randomly allocated to continued cyclical chemotherapy or not further c...

Fig. 1. Time course for a patient with refractory Burkitt’s leukemia who suffered from fungemia due to Trichosporon dermatis after chemotherapy. Abbreviations: R-hyper CVAD, rituximab+cyclophosphamide hydrate+vincristine sulfate+doxorubicin hydrochloride+dexamethasone; MTX, methotrexate; R-IVAC, rituximab+ifosfamide+etoposide+cytarabine; R-CODOX-M, rituximab+cyclophosphamide hydrate+vincristine...

A rare case of double Philadelphia chromosome-positive B Acute lymphoblastic Leukaemia (B-ALL) is reported here. A 60-year-old lady presented with one month history of fever, submandibular lymphadenopathy, loss of appetite and weight loss. Physical examination revealed multiple palpable cervical lymph nodes. Blood film showed leucocytosis with 72% blasts. Bone marrow assessment confirmed a diag...

BACKGROUND Relapsing primary central nervous system lymphoma carries a poor prognosis when treated with conventional chemotherapy with a one-year overall survival of 25-40%. Encouraging results have been shown with intensive chemotherapy followed by autologous hematopoietic stem cell rescue. We report the results of a large multicenter retrospective analysis of intensive chemotherapy followed b...