نتایج جستجو برای: mexab
تعداد نتایج: 200 فیلتر نتایج به سال:
target modification and reduced drug accumulation are the main resistance mechanisms against fluoroquinolone antibiotics in pseudomonas aeruginosa. we performed a genotypic characterization of three major mex multidrug efflux pumps (mexab-oprm, mexxy-oprm and mexcd-oprj) in ciprofloxacin resistant clinical isolates of p. aeruginosa, collected from tehran, iran this was followed by sequencing a...
MexR is a MarR family protein that negatively regulates multidrug efflux systems in the human pathogen Pseudomonas aeruginosa. The mechanism of MexR-regulated antibiotic resistance has never been elucidated in the past. We present here that two Cys residues in MexR are redox-active. They form intermonomer disulfide bonds in MexR dimer with a redox potential of -155 mV. This MexR oxidation leads...
One hundred and forty-three non-repetitive strains of Pseudomonas aeruginosa were collected in 13 French hospitals in 1997. A decreased susceptibility or resistance to ticarcillin (MIC > 16 mg/L) was found in 61 isolates (43%) and this was attributed to three major mechanisms: (i) overexpression of OprM and hence related efflux components such as MexAB or MexXY (42.6%), (ii) production of acqui...
Background. Pseudomonas aeruginosa is a causative agent of nosocomial infections. Chloramphenicol broad-spectrum, inexpensive, and common antibiotic. MexAB-OprM secretory pump that causes the innate resistance this bacterium. This study aimed to evaluate expression MexA gene under treatment copper nanoparticles chloramphenicol. Methods. In study, 49 samples were collected from 11 laboratories i...
Tripartite multidrug efflux systems of Gram-negative bacteria are composed of an inner membrane transporter, an outer membrane channel and a periplasmic adaptor protein. They are assumed to form ducts inside the periplasm facilitating drug exit across the outer membrane. Here we present the reconstitution of native Pseudomonas aeruginosa MexAB-OprM and Escherichia coli AcrAB-TolC tripartite Res...
While much attention has been focused on acquired antibiotic resistance genes, chromosomal mutations may be most important in chronic infections where isolated, persistently infecting lineages experience repeated antibiotic exposure. Here, we used experimental evolution and whole-genome sequencing to investigate chromosomally encoded mutations causing aztreonam resistance in Pseudomonas aerugin...
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