BACKGROUND Matrix Gla protein (MGP) is an extrahepatic protein that is dependent on glutamate carboxylation, a vitamin K-dependent process. Its dysfunctional form, desphospho-uncarboxylated-MGP, has been associated with increased arterial calcification and stiffness. The aim of this study was to measure the degree of postoperative carboxylation of MGP and two other Gla proteins in patients sche...

Thyroid hormones have marked cardiovascular effects in vivo. However, their direct effects on vascular smooth muscle cells have been unclear. Because thyroid hormones play critical roles in bone remodeling, we hypothesized that they are also associated with vascular smooth muscle calcification, one of the pathological features of vascular sclerosis. To test this hypothesis, we examined the effe...

PURPOSE To investigate the impact of meibomian gland probing (MGP) on meibomian gland (MG) area from the upper lids of patients with obstructive meibomian gland dysfunction (o-MGD). METHODS Retrospective study comparing pre-MGP/post-MGP non-contact infrared meibography results in patients with o-MGD, viewing signs of MG growth within total measurement field. RESULTS Post-MGP meibography of ...

Matrix Gla protein (MGP) is a phosphorylated and γ-carboxylated protein that has been shown to prevent the deposition of hydroxyapatite crystals in the walls of blood vessels. MGP is also expressed in kidney and may inhibit the formation of kidney stones, which mainly consist of another crystalline phase, calcium oxalate monohydrate. To determine the mechanism by which MGP prevents soft-tissue ...

OBJECTIVE To describe the outcomes of a public hospital maternity unit in rural New South Wales (NSW) following the adaptation of the service from an obstetrician and general practitioner-obstetrician (GPO)-led birthing service to a low-risk midwifery group practice (MGP) model of care with a planned caesarean section service (PCS). DESIGN A retrospective descriptive study using quantitative ...

OBJECTIVE Vascular and valvular calcifications are pathological processes regulated by resident cells, and depending on a complex interplay between calcification promoters and inhibitors, resembling skeletal metabolism. Here, we study the role of the vitamin K-dependent Gla-rich protein (GRP) in vascular and valvular calcification processes. APPROACH AND RESULTS Immunohistochemistry and quant...

AIM: To evaluate the potential of two trabecular meshwork (TM)-specific promoters, Chitinase 3-like 1 (Ch3L1) and matrix gla protein (MGP), for improving specificity safety in glaucoma gene therapy based on self-complementary AAV2 (scAAV2) vector technologies. METHODS: An scAAV2 with C3 transferase (C3) as reporter (scAAV2-C3) was selected. The scAAV2-C3 vectors were driven by Ch3L1 (scAAV2-Ch3...

This paper gives a detailed introduction of implementing mixture Gaussian process (MGP) model and develops its application for Bayesian optimization (BayesOpt). The also techniques MGP in finding components introduced an alternative gating network based on the Dirichlet distributions. BayesOpt using resultant significantly outperforms one regression terms efficiency test tuning hyperparameters ...

Matrix Gla protein (MGP) is a small secreted and requires vitamin K dependent γ-carboxylation for its function. MGP has been identified as local inhibitor of vascular calcification because MGP-deficient mice die due to severe arterial resulting rupture. Clinical trials revealed that reduction in active predicts poor prognosis patients cardiovascular complications. However, recent studies showed...

A microcosm study was conducted in Okeechobee, County, Florida, to evaluate the P removal potential of several aquatic macrophytes and "unconventional" terrestrial crops cultured on dairy lagoon wastewaters. Existing conventional spray field crops in this region that are irrigated with dairy wastewaters are estimated to remove 23 mgP/m-'-day. Effects of season and hydraulic retention time (HRT)...