BACKGROUND The influence of hypertension on cardiovascular risk is well known. Ambulatory blood pressure measurement (ABPM) is able to identify patients with masked hypertension (MH) underdetected by clinical BP measurement. The benefit of screening for MH in a high-risk population was investigated. AIMS To detect MH in a population with no prior history of hypertension and medically treated ...

The present study aimed to determine the effects of mannoheptulose (MH) (8 mg/kg) on energy expenditure (EE), respiratory quotient (RQ) and glycaemic response in healthy adult Beagle dogs (n 8; 9·62 (SEM 0·31) kg; body condition score 4·5). The study was designed as replicated 4 × 4 Latin squares with a 2 × 2 factorial treatment structure. The dietary treatments were low carbohydrate (CHO) rela...

Solutions of chloranil (CA) in benzene were irradiated in the presence of Moore's hydrocarbon (MH) and 2-norcarene (NC). These reactions brought about four common products, namely 2,3,5,6-tetrachlorohydroquinone (TCH) and three 1 : 1 cycloadducts, whose C7H10 subunits were reorganised in comparison to the skeletons of MH and NC. As the fifth product, a norcar-3-en-2-yl ether of TCH was formed i...

widely used to generate coherent light at frequencies at which laser light is unavailable. Standard devices can have a very high efficiency (close to 100%), but they employ pure, sizeable — and hence expensive — nonlinear single crystals, and require careful adjustments. On page 374 of this issue, Baudrier-Raybaut et al. show that efficient optical frequency conversion can be achieved in disord...

It is not every day that a ‘law of nature’ is challenged by empirical data, but on page 457 of this issue we find just that. Peter Reich and colleagues offer convincing evidence that refutes the idea that Kleiber’s law — the all-encompassing prediction that metabolic rate should scale as the 3/4 power of size across animals — can be extended to vascular plants (Fig. 1). Their findings question ...

Measurements of stream flow around the world have documented an increase in the amount of water that runs off the continents and returns to the ocean. This trend has been occurring since the beginning of the century, yet changes in precipitation over land do not sufficiently account for this increase. On page 835 of this issue, Gedney et al. identify an important contributor to increasing globa...

817 configuration.A similar meiotic structure occurs in a few disparate organisms, such as evening primrose and termite, but it has not been seen before in vertebrates. Grützner and colleagues have created fluorescent ‘paints’ for individual platypus chromosomes. By tagging the chromosomes in this manner, they could determine the number of copies of each chromosome in males and females,and thei...

Malignant Hyperthermia (“MH”)—the rapid onset of extremely high fever with muscle rigidity—is caused by a runaway heat production futile cycle mediated via the sodium channels at the myoneural receptor sites. MH is not triggered by non-depolarizing muscle relaxants; however, depolarizing muscle relaxants may trigger it [1]. Here we present a de novo hypothesis of how MH is triggered and develop...

Results A total of 47 medical records were identified and reviewed by three experts. The mean age of patients was 40 years and 49% were male. A surgical procedure with general anesthesia was documented in 68% of patients. However, only 23.4% were judged to have had a possible, probable, or fulminant MH event. Dantrolene was given in 81% of MH cases. Family and personal history of MH accounted f...

Plasma DBH and platelet MAO activities were measured by radioenzymatic assay in 10 Large-White and 20 Piétrain pigs 9 to 11 weeks old. Piétrain pigs within the same litter, challenged by halothane, were classified as malignant hyperthermia (MH) susceptible or not according to their reaction. The Large-White pig strain was not susceptible to MH. Plasma DBH activity did not differ according to st...