Japanese encephalitis virus (JEV) and Akabane (AKAV) are mosquito-borne viruses that cause reproductive disorders in horses cattle, respectively. There is no treatment for JEV or AKAV infections animals. Therefore, we evaluated the antiviral activity of 18-mer amphipathic peptides 1b-4/21-C series on using Vero cells vitro their effects mice. Of 6 peptides, 1b-4/21-C12 had lowest IC50 0.313 aga...

background: in leishmaniasis, some drugs prescribed for treatment have toxic ef-fects and there are reports about drug resistance in some countries. due to this fact, using herbal drugs such as artemisinin with good efficacy and low toxic effect might be suitable. methods: we evaluated the apoptotic effect of artemisinin on leishmania major in vitro and the antileishmanial activities of artemis...

introduction: as a physical treatment, electrochemical therapy (echt) has provided an effective and useful  approach  for  treating  localized  tumors.  the  chemical  changes  due  to  a  direct  electric  current  destroy  the  tumor. this study evaluates the effect of electrical dose and polarity on the efficacy of the treatment of a  colon tumor model.  materials and methods: in order to in...

Background & Aims Mutations in the APC gene and other genes Wnt signaling pathway contribute to development of colorectal carcinomas. R-spondins (RSPOs) are secreted proteins that amplify intestinal stem cells. Alterations RSPO have been identified human tumors. We studied effects RSPO1 overexpression ApcMin/+ mutant mice. Methods An adeno associated viral vector encoding RSPO1-Fc fusion protei...

experimental allergic encephalomyelitis (eae), a demyelinating disease induced in the animals parallels multiple sclerosis in human in several aspects, provides a useful model to investigate multiple sclerosis. in this study, we have therefore used this model to study functions of nerve growth factor (ngf) in eae. ngf with considerable effects on neuron survival, proliferation and differentiati...

background : bacterial infections in burn and wound patients are common and difficult to control. the aim of the current study was to evaluate the ability of full length oprf to elicit the production of protective igg in mice burn wound sepsis model against p. aeruginosa infection. methods : oprf protein was expressed and purified by ni-nta. the purified protein as used to immunize balb/c mice....

Background: The cerebellum is an area of the brain that prone to damage in individuals with Alzheimer’s disease (AD). As a non-pharmacological intervention for AD, exercise training has shown ameliorating effect on AD pathology; however, target regions have mostly been cerebral cortex and hippocampus. main aim this study was explore influence 12 weeks treadmill running accumulation AD-related p...

introduction: epidermal growth factor receptor (egfr) has been shown to play a critical role in tumor cell growth and its overexpression has been observed in many epithelial tumors. in the field of cancer vaccine research, displaying the peptide mimotope on the surface of phage particles has shown promising results. methods: in this study using m13-pviii phage display system, two constructs wer...

T cell with chimeric antigen receptors (CAR-T) has presented remarkable efficacy for blood cancer as an emerging immunotherapy. However, solid tumors, the therapeutic is much impaired due to lack of infiltration and persistence CAR-T in tumor tissue. Thus, we constructed interleukin-7-loaded oncolytic adenovirus combined use virus improve outcome. We (oAD-IL7) a B7H3-targeted explored single oA...

Background: Ceramide and sphingosine-1-phosphate (S1P) play opposing roles in cell death survival, maintain a dynamic balance called the sphingolipid rheostat. Glucosylceramide is substrate to generate ceramide but its effect on breast cancer by oral administration was never tested. The purpose of this study reveal anticancer activity glucosylceramide potential as new therapeutic agent cancer. ...