Bearing in mind the present scenario of the increasing biological tolerance of bacteria against antibiotics, a time controlled two pulse dosage form of amoxicillin was developed. The compression coating inlay tablet approach was used to deliver the drug in two pulses to different parts of the GIT after a well defined lag time between the two releases. This was made possible by formulating a cor...

9-[1-(2-Methyl-4-methoxyphenyl)]-6-hydroxy-3H-xanthen-3-one (2-Me-4-OMe TG) is a fluorescein derivative dye whose photophysical properties show a remarkable pH dependence. In aqueous solution the fluorescence quantum yield (Φf) of its anionic species is nearly a hundred times higher than that of its neutral species. Such a large difference in Φf makes 2-Me-4-OMe TG useful as an "on-off" pH indi...

Characterization, understanding and overcoming barriers of enzymatic hydrolysis of different raw materials is essential for the development of economically competitive processes based on enzymatic treatments. This work focused on factors relevant for the improvement of enzymatic hydrolysis of lignocellulose raw materials derived from softwood. The major interest of the work was in lignin. Speci...

The inactive ingredients contained in propranolol hydrochloride extended-release capsules, USP are ethylcellulose, gelatin, hypromellose, microcrystalline cellulose, sodium lauryl sulfate and titanium dioxide. In addition, propranolol hydrochloride extended-release capsules, USP 60 mg, 120 mg, and 160 mg capsules contain FD&C Blue No. 1. Propranolol hydrochloride extendedrelease capsules, USP a...

This paper compares the water sorption behavior of commercial microcrystalline celluloses with those of cellulose II materials using several nonlinear models. Aqueous dispersions of cellulose II were spray-dried employing an inlet drying air temperature of 195 °C; atomizing air pressure of 1.0 kg-f/cm; drying air flow-rate of 0.44 m/min; feed flow-rate of 2.0 mL/min and nozzle diameter of 0.7 m...

The specific aim of this study was to prepare sustained release matrix tablets containing indapamide as a low dose and low water solubility model drug. The matrix formers were composed of blends of hydroxypropyl methylcellulose as a swellable polymer and methyl cellulose as an erodible polymer. The matrix tablets were prepared by the direct compression technique and they have shown robust and a...

In this study, the kinetics of the acid catalyzed hydrolysis of microcrystalline cellulose (Avicel PH101) to levulinic (LA) and formic (FA) acids was investigated in a batch reactor over the following range of conditions: 160–200 C, hydrochloric acid concentrations of 0.309–0.927 M (11.3–33.8 g/l), cellulose concentrations of 49.8–149 mM (8.06–24.1 g/l), and residence times of 0–50 min. The max...

The organization of water molecules adsorbed onto cellulose and the supramolecular hydrated structure of microfibril aggregates represents, still today, one of the open and complex questions in the physical chemistry of natural polymers. Here, we investigate by 2H MAS NMR the mobility of water molecules in carefully 2H-exchanged, and thereafter re-dried, microcrystalline cellulose. By subtracti...