A diffusion-based microreactor system operated with a reaction volume of 8 μL is presented and characterized to intensify the process understanding in microscale cultivations. Its potential as screening tool for biological processes is evaluated. The advantage of the designed microbioreactor is the use for the continuous cultivation mode by integrating online measurement technique for dissolved...

Pharmaceutical drug formulations in the nanometer scale received significant interest during the last years as they provide the possibility to stabilize drugs and to transport them directly to their target. Biodegradable self-assembled nanoparticles consisting of protamine and oligonucleotides, so-called “proticles”, have already been successfully developed for different applications [1, 2]. Ho...

PEM fuel cells utilizing hydrogen and oxygen have shown great promise as future sources of clean, efficient power. Due to difficulties encountered in hydrogen storage and transport, investigation of on-board generation of hydrogen via fuel processing of liquid hydrocarbons has gained prominence. To achieve these goals, the need for compact reactor systems with effective component and heat integ...

Abstract Continuous flow calorimeters are a promising tool in process development and safety engineering, especially for chemistry applications to characterize the heat release kinetic parameters of rapid chemical reactions. In this study, digital accompaniment an isoperibolic calorimeter characterization exothermic reactions is presented. To support experimental planning evaluation, computatio...

With a miniaturized (3 microL volume) fiber-optics based system for on-line measurement by UV/Vis spectroscopy, the reaction rate constants (at different pressures) and the activation volumes (deltaV(not =)) were determined for a nucleophilic aromatic substitution and an aza Diels-Alder reaction in a capillary microreactor.

The use of FeCl(3) resulted in a fast homocoupling of aryllithiums, and this enabled its integration with the halogen-lithium exchange reaction of aryl halides in a flow microreactor. This system allows the homocoupling of two aryl halides bearing electrophilic functional groups, such as CN and NO(2), in under a minute.

A scalable method for the preparation of 4,5-disubstituted thiazoles and imidazoles as distinct regioisomeric products using a modular flow microreactor has been devised. The process makes use of microfluidic reaction chips and packed immobilized-reagent columns to effect bifurcation of the reaction pathway.