In the undertaken study cross linked egg albumin microspheres of progesterone (PG) have been investigated through the nasal route. A smooth, spherical, cross-linked egg albumin microsphere in the size range of 15-37 μm loaded with progesterone were prepared by multiple emulsion (o/w/o) method by glutarldehyde cross-linking and thermal denaturation techniques. Microspheres were prepared by using...

Purified fibroin protein can be obtained in large quantities from silk fibers and processed to form microscopic particles as delivery vehicles for therapeutic agents. In this study, we demonstrated that fibroin microspheres were taken up by 3T3 cells, localized in the nonlysosomal compartment, and secreted from the cytoplasm after medium replenishment. DNA-loaded microspheres were taken up by >...

Silicone microspheres are exceedingly difficult to make. Here, polydimethylsiloxane microspheres (≈1 μm diameter) are synthesized using ultrasonic spray pyrolysis, the first demonstration of a scalable synthetic procedure for crosslinked silicone microspheres. This continuous, aerosol process is also used to directly produce fluorescent, magnetic, and copolymeric derivatives; the potential biom...

The purpose of this study was to prepare polymeric microspheres containing Ketoprofen (KFN) by single emulsion [oil-in-water (o/w)] solvent evaporation method. Polycaprolactone (PCL), biocompatible polymer, was used for the preparation of sustained released microspheres of KFN. A Plackett–Burman design was employed by using the Design-Expert® software (Version9.0.3.1, Stat-Ease Inc., Minneapoli...

The aim of this study was to prepare docetaxel-loaded chitosan microspheres and to evaluate their in vitro and in vivo characteristics. Glutaraldehyde crosslinked microspheres were prepared using a water-in-oil emulsification method, and characterized in terms of the morphological examination, particle size distribution, encapsulation ratio, drug-loading coefficient and in vitro release. Pharma...

This study focuses on the use of bio-nanocomposite microspheres, consisting of carbonated hydroxyapatite (CHAp) nanospheres within a poly(L: -lactide) (PLLA) matrix, to produce tissue engineering (TE) scaffolds using a modified selective laser sintering (SLS) machine. PLLA microspheres and PLLA/CHAp nanocomposite microspheres were prepared by emulsion techniques. The resultant microspheres had ...

The purpose of this study was to prepare and characterize microspheres loaded by Aceclofenac. To achieve this goal Chitosan and Sodium alginate microspheres loaded by Aceclofenac were prepared by emulsification and ionic gelation methods. Morphology, size, encapsulation efficiency and drug release from these microspheres were evaluated. Microscopic evaluation of microspheres showed that microsp...

Hierarchical, core-shell structured microspheres of bismuth chalcogenides (Bi2E3, E ) S, Se, Te) have been synthesized by chemical transformation of reactive precursor templates, which involves the formation of intermediate BiOCl mircrospheres and their subsequent hydrothermal transformation into Bi2E3 core-shell microspheres. The uniform precursor microspheres consisting of BiOCl nanoplates we...

In this study, gelatin microspheres containing lactic acid were prepared by the polymerization technique using glutaraldehyde as the cross-linking agent. Dried microspheres were loaded by immersing them in an aqueous solution of lactic acid. In order to prepare microspheres with an appropriate drug release profile, the effect of time of cross-linking and the amount of cross-linking agent on the...

A new approach for attaining sustained release of protein is introduced, involving a pore-closing process of preformed porous PLGA microspheres. Highly porous biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres were fabricated by a single water-in-oil emulsion solvent evaporation technique using Pluronic F127 as an extractable porogen. Recombinant human growth hormone (rhGH) was...