INTRODUCTION Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD). One of the earliest manifestations of CVD is endothelial dysfunction (ED). ED can occur in both the microcirculation and the macrocirculation, and these manifestations might be relatively independent of each other. Little is known about the association between endothelial function in ...

BACKGROUND Diabetes mellitus (DM) is a metabolic disorder complicated by microvascular and macrovascular diseases. The clinical profile of these complications has not been adequately studied in many tertiary health care centers in India. AIM The authors studied the clinical profile of microvascular diabetes complications [peripheral sensory neuropathy (PSN), diabetic retinopathy (DR), nephrop...

One of the most global health problems today is SARS-CoV-2 coronavirus pandemic and its numerous complications. COVID-19 was first reported in China city Wuhan December 2019. It found that infection leads to microvascular macrovascular complications throughout body. Recent data indicate a strong link between severe clinical manifestations an increased risk thromboembolism. associated with sever...

Of all the complications of diabetes mellitus, macrovascular complications, ie, large-vessel atherosclerosis, account for the largest share of morbidity, mortality, and health care expenditures. Whereas there is now highly persuasive evidence that glycemic control reduces the risk of microvascular complications in type 1 diabetes, and probably in type 2 diabetes as well, such evidence is unavai...

The primary objective of treating all patients with diabetes is to establish and maintain near-normal blood glucose levels to prevent microvascular and macrovascular complications. The glycated hemoglobin (HbA(1c)) is the accepted standard for monitoring overall glycemic control with treatments and management strategies traditionally targeting fasting and preprandial glucose levels. However, po...

OBJECTIVE To compare diabetes care and outcomes among Haitians, African Americans, and non-Hispanic whites. RESEARCH DESIGN AND METHODS We analyzed data from 715 Haitian, 1,472 African American, and 466 non-Hispanic white adults with diabetes using χ² testing and multiple logistic regression. RESULTS Haitians had a higher mean A1C than African Americans (8.2 ± 1.9 vs. 7.7 ± 2.0%) and non-Hi...

Oxidative stress, through the production of reactive oxygen species (ROS), has been proposed as the root cause underlying the development of insulin resistance, beta-cell dysfunction, impaired glucose tolerance and type 2 diabetes mellitus (T2DM). It has also been implicated in the progression of long-term diabetes complications, including microvascular and macrovascular dysfunction. Excess nou...