This study aims to evaluate the effect of combined use of the racemic flavanone Naringenin (NRG) and the protein sericin as TNF-α blockers. Sericin (SMs) and (R/S) NRG-loaded Sericin (SNRGMs) microparticles were prepared by spray-drying, characterized in terms of morphology and particle size distribution, and encapsulation efficiency was determined. Concerning morphology and particle size distr...

Objective : analyzing the acquisition and monthly costs for patients on modern fixed-dose antihypertensive combinations in three regions of Far Eastern Federal District. Material methods . Intra-group analysis retail drugs 2019 drugstores Khabarovsk Region, Sakhalin Amur Region (n=100) was carried out. The calculation cost therapy performed total sales indicators were identified. Statistical an...

atrial fibrillation (af) is the most common complication of coronary artery bypass graft surgery (cabg). the reported incidence of af after cabg varies from 20% to 40%. postoperative af (poaf) is associated with increased incidence of hemodynamic instability, thromboembolic events, longer hospital stays, and increased health care costs. a variety of pharmacological and nonpharmacological strate...

benign prostatic hyperplasia generally affects males above fourty years of age and has significant effect in overall quality of life (qol). this is one of the cause of millions of dollors in healthcare expenditure. alpha one adrenoreceptor blockers are frequently used for the benign prostatic enlargement because of their significant effect on storage and voiding symptoms, qol, flow rate and pos...

Objective: In a previous work, we showed that asafoetida essential oil (AEO), from oleo-gum resin of Ferula asafoetida L. from the Apiaceae family, has a vasodilatory effect. This effect was both endothelium-dependent and endothelium-independent. The present study was designed to determine whether potassium channels and intracellular calcium release contribute to AEO-i...

BACKGROUND Limited data exist on whether the cardioprotective benefit of beta-blockers is modified by the presence of chronic kidney disease (CKD). METHODS A post hoc analysis of the data from the Bezafibrate Infarction Prevention (BIP) study was performed. CKD was defined according to the Modification of Diet in Renal Disease (MDRD) equation as an estimated glomerular filtration rate (GFR) <...

The relationships between blood pressure variability (BPV) and cerebral blood flow variability (CFV) across individuals in the presence of intact and blunted cerebrovascular control are poorly understood. This study sought to characterize the interindividual associations between spontaneous BPV and CFV under conditions of normal and blunted [calcium channel blockade (CCB)] cerebrovascular contr...

Recent evidence from randomized controlled trials has provided compelling evidence to support the use of beta blockers in most patients with heart failure due to systolic dysfunction. There is little disagreement about the mortality benefit provided by adding beta blockers to standard therapy, which may include angiotensin-converting enzyme inhibitors, diuretics, and sometimes digoxin. A few ar...