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BACKGROUND Survival analysis using time-updated CD4+ counts during antiretroviral therapy is frequently employed to determine risk of clinical events. The time-point when the CD4+ count is assumed to change potentially biases effect estimates but methods used to estimate this are infrequently reported. METHODS This study examined the effect of three different estimation methods: assuming i) a...

The understanding of inequalities in convexity is crucial for studying local fractional calculus efficiency many applied sciences. In the present work, we propose a new class harmonically convex functions, namely, generalized ψ - id="M2"> s -convex functions based on fractal set technique establishing Hermite-Ha...

The authors' previous study with an eye camera revealed that when asked to mark the centre of a line patients with left unilateral spatial neglect persist in fixating a point on its right part and place the subjective midpoint there without searching leftwards. The present study examined the patterns of leftward search of nine patients with left unilateral spatial neglect when they were require...

The midpoint method or technique is a “measurement” and as each measurement it has a tolerance, but worst of all it can be invalid, called Out-of-Control or OoC. The core of all midpoint methods is the accurate measurement of the difference of the squared distances of two points to the “polar” of their midpoint with respect to the conic. When this measurement is valid, it also measures the diff...

We present two new experimental methods of realizing the desired kinematics in a filament stretching rheometer. Due to the presence of the rigid plates connecting the fluid filament in this device, a homogeneous uniaxial elongational flow cannot be imposed throughout the entire fluid filament. However, if the fluid element at the midpoint of the filament is forced to contract in the same manner...

In this paper, we present a novel Lagrangian formulation of the equations of motion for point vortices on the unit 2-sphere. We show first that no linear Lagrangian formulation exists directly on the 2-sphere but that a Lagrangian may be constructed by pulling back the dynamics to the 3-sphere by means of the Hopf fibration. We then use the isomorphism of the 3-sphere with the Lie group SU(2) t...

OBJECTIVES/HYPOTHESIS To investigate possible association of hearing loss and SLC26A4 mutations with the subgroups of enlarged vestibular aqueduct (EVA) morphology in Japanese subjects with hearing loss. STUDY DESIGN Retrospective multicenter study. METHODS Forty-seven subjects who had vestibular aqueduct with midpoint diameter >1 mm by computed tomography of the temporal bone were enrolled...