Piper solmsianum C. DC. var. solmsianum (Piperaceae) is a shrub commonly found in areas with wet tropical soils. Other Piper species have been used in folk medicine as antitumoral and antiseptic agents. We studied the crude methanolic extract, some organic fractions and compounds isolated from this plant for possible antimicrobial activity against Gram-positive and Gram-negative bacteria. The b...

Sida acuta is a shrub indigenous to pantropical regions. The plant is widely used for its various pharmacological properties. Among compounds of pharmacological interest occurring in the plant, are indoloquinoline alkaloids. The aim of the present study was to investigate the antimicrobial activity of alkaloids of S. acuta from Burkina Faso. The alkaloids had a good antimicrobial activity again...

Bedaquiline (BDQ) has been proven to be effective in the treatment of multidrug-resistant tuberculosis. We hypothesized that BDQ could be a potential agent to treat nontuberculous mycobacterial (NTM) infection. The objective of this study was to evaluate the in vitro activity of BDQ against rapidly growing mycobacteria by assessing the minimal inhibitory concentration (MIC) and minimal bacteric...

To demonstrate different effects of garlic extracts and their main antibiotic substance allicin, as a template for investigations on the antibacterial activity of food ingredients. Staphylococcus epidermidis ATCC 12228 and the isogenic biofilm-forming strain ATCC 35984 were used to compare the activity of allicin against planktonic bacteria and bacterial biofilms. The minimal inhibitory concent...

The effect of protein binding on antibiotic efficacy is controversial. The pharmacologic effect of an antibiotic is believed to be related to its unbound concentration at the site of infection. It is unknown whether antibiotics with a low degree of serum protein binding are clinically superior to antibiotics that are highly protein bound. In a randomized, crossover investigation, the serum bact...

Antimicrobial activity of honey has lately drawn researchers’ attention, especially due to the fact that its antimicrobial capacity been proven. The aim this study was analyzing bactericidal and bacteriostatic action in pathogenic microorganisms Staphylococcus aureus, Escherichia coli Candida albicans samples from five regions state Paraná. yeast showed be more resistant than bacteria aureus. m...

rue, ruta graveolens, is a medicinal plant in traditional medicine that has several therapeutic properties such as anti-carcinogenic agent, antioxidant, anti-inflammatory, antimicrobial, hypotensive, and spasmolytic. this study was carried out to evaluate the antibacterial effects of the etanolic extract of rue against piscine pathogenic bacteria viz. lactococcus garvieae and aeromonas hydrophi...

BACKGROUND The development of new drugs or alternative therapies effective against methicillin-resistant Staphylococcus aureus (MRSA) is of great importance, and various natural anti-MRSA products are good candidates for combination therapies. We evaluated the antibacterial activities of a Phellinus baumii ethyl acetate extract (PBEAE) and its synergistic effects with β-lactams against MRSA. ...

Correspondence: Danka Galabova Department of General Microbiology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev St., Block 26, 1113 Sofia, Bulgaria e-mail: [email protected]; ABSTRACT The resistance of bacteria to antibiotics is a serious public problem with increasing significance. The development of novel pharmaceuticals with wide spectrum...