Resistance to cancer treatment is one of the major challenges currently faced when treating gastrointestinal (GI) cancers. A contributing factor this resistance presence stem cells (CSCs) in GI cancers (e.g., colorectal, pancreatic, gastric, liver cancer). Non-coding RNAs, such as microRNAs (miRNAs), have been found regulate several key targets that are responsible for stemness, and function on...

MicroRNAs (miRNAs) are small non-coding RNAs that have a key role in the regulation of gene expression. The importance miRNAs is widely acknowledged by community nowadays and computational methods needed for precise prediction novel candidates to miRNA. This task can be done searching homologous with sequence alignment tools, but results restricted sequences very similar known miRNA precursors ...

in the retinoblastoma research, it is of great interest to identify molecular markers associated with the genetics of tumorigenesis. micrornas (mirnas) are small non-coding rna molecules that play a regulatory role in many crucial cellular pathways such as differentiation, cell cycle progression, and apoptosis. a body of evidences showed dysregulation of mirnas in tumor biology and many disease...

microRNAs (miRNAs) are promising biomarkers for different pathological models because of their stable and detectable characters in biofluids. Here, we collected urine samples from 5 beagle dogs on the 3th, 6th, 12th day an acute kidney injury (AKI) caused by gentamycin. miRNA levels were measured with high-throughput sequencing results then differentially investigated. Gene Ontology (GO) KEGG p...

MicroRNAs (miRNAs) are small non-coding regulatory RNAs molecules with a size of approximately 22 nucleotides that are implicated in regulating gene expression at the post-transcriptional regulatory levels. Inflammatory disorders especially autoimmune diseases (ADs) occur from an abnormal immune response of body against cells of their own specific tissues or multiple organ systems leading to ch...

Small-cell lung cancer (SCLC) is a type of cancer, accounting for approximately 15% cancers. SCLC significantly associated with early recurrence, metastasis, and poor prognosis, 2-year survival rate after therapy, which <5%. The molecular mechanisms underlying the development are not clear. In this study, we identified SCLC-specific biomarkers by evaluating differential expression mRNA micro...

Hypertension is a cardiovascular disease which very common hemodynamic syndrome, and it has different prevalence in regions as all over the world. In recent studies, known that microRNAs (miRNAs) play an important role hypertension miRNA expressions are regulated by epigenetic mechanisms. There also studies proving new therapeutic targets for pulmonary arterial hypertension, miRNAs can particip...