Direct equipartition ray design was used to construct Cd-Ni and Cd-Cr binary mixtures. Microplate toxicity analysis was used to evaluate the toxicity of individual substance and the Cd-Ni and Cd-Cr mixtures on Chlorella pyrenoidosa and Selenastrum capricornutum. The interacting toxicity of the mixture was analyzed with concentration addition (CA) model. In addition, combination index method (CI...

Insulin-producing cells are known for their extremely low antioxidant equipment with hydrogen peroxide (H(2)O(2))-inactivating enzymes. Therefore, catalase was stably overexpressed in mitochondria and for comparison in the cytoplasmic compartment of insulin-producing RINm5F cells and analyzed for its protective effect against toxicity of reactive oxygen species (ROS) and proinflammatory cytokin...

Effects of binary mixtures of six metal oxide nanoparticles (NPs; 54 combinations) on the activities of seed germination and bacterial bioluminescence were investigated using the theory of probability. The observed toxicities of various NPs combinations were compared with the theoretically expected toxicities, calculated based on individual NPs toxicities. Different sensitivities were observed ...

This document provides a review of the environmental fate of esfenvalerate, chemical name: (S)-αcyano-3-phenoxybenzyl-(S)-2-(4-chlorophenyl)-3-methylbutyrate. Esfenvalerate is a mixture of four stereoisomers (Table 1), enriched with the S,S-isomer, the most insecticidally active isomer. The parent mixture, fenvalerate, is a mixture of the same four isomers in relatively equal proportions (Table...

Sym004 is a new antibody mixture to target EGFR in metastatic colorectal cancer. Preclinical data suggest efficacy in anti-EGFR-resistant tumors, but it remains unclear whether a higher toxicity is outweighed by those advantages.

Marine bacterial isolates cultured from the digestive tracts of blue mussels (Mytilus edulis) contaminated with paralytic shellfish toxins (PSTs) were screened for the ability to reduce the toxicity of a PST mixture. Seven isolates reduced the overall toxicity of the algal extract by > or = 90% within 3 days. These isolates shared at least 99% 16S rRNA gene sequence similarity with five Pseudoa...

We examined the toxicity mitigation efficiency of a hydrologically modified backwater wetland amended with a pesticide mixture of atrazine, metolachlor, and fipronil, using 96 h survival bioassays with Hyalella azteca. Significant H. azteca 96 h mortality occurred within the first 2 h of amendment at the upstream amendment site but not at any time at the downstream site. H. azteca survival vari...

Petroleum products and essential oils are produced used in large amounts categorized as Substances of Unknown or Variable composition, Complex reaction Biological materials (UVCBs). These UVCBs notorious difficult-to-test substances, since they complex mixtures hydrophobic volatile compounds. This study introduces two passive dosing (PD) approaches for whole UVCB toxicity testing: (1) headspace...