OBJECTIVE To assess the relationship between lifestyle prior to the event and functional recovery at hospital discharge after acute stroke. DESIGN Cohort study. PATIENTS A sample of 191 patients with first stroke episode (87.4% ischaemic). METHODS Severity of the event at admission was measured by the Modified National Institutes of Health Stroke Scale. The Frenchay Activity Index was use...

Background and Purpose—Tandem internal carotid and middle cerebral artery occlusion independently predicts poor outcome after intravenous thrombolysis. Recanalization of internal carotid artery dissection by stent-assisted angioplasty has recently been proposed when anticoagulation fails to prevent a new ischemic event. We recently reported a case of tandem internal carotid and middle cerebral ...

BACKGROUND AND PURPOSE The traditional time window for acute ischemic stroke intra-arterial therapy (IAT) is <6 hours, which is based on pharmacological thrombolysis without penumbral imaging. This study was conducted to determine the safety of patient selection for IAT based on perfusion mismatch rather than time. METHODS A cohort of consecutive patients treated with IAT was identified by da...

BACKGROUND AND PURPOSE The Middle Cerebral Artery Embolism Local Fibrinolytic Intervention Trial (MELT) Japan was organized to determine the safety and clinical efficacy of intraarterial infusion of urokinase (UK) in patients with stroke within 6 hours of onset. METHODS Patients with ischemic stroke presenting within 6 hours of onset and displaying occlusions of the M1 or M2 portion of the mi...

BACKGROUND AND PURPOSE Patients with right hemispheric stroke (RHS) have been reported to have fewer good outcomes after thrombolysis. We aimed at evaluating outcome after stroke thrombolysis with regards to the affected hemisphere controlling for stroke lesion volume as a potential confounder. METHODS We retrospectively analyzed data from a prospective study of patients with acute stroke tre...

BACKGROUND AND PURPOSE Minor stroke and transient ischemic attack with an intracranial occlusion are associated with neurological deterioration and disability. Tenecteplase (TNK-tissue-type plasminogen activator) compared with alteplase is easier to administer, has a longer half-life, higher fibrin specificity, possibly a lower rate of intracranial hemorrhage, and may be an ideal thrombolytic a...