نتایج جستجو برای: moisture adjustment factor maf

تعداد نتایج: 947572  

Journal: :Cancer cell 2004
Elaine M Hurt Adrian Wiestner Andreas Rosenwald A L Shaffer Elias Campo Tom Grogan P Leif Bergsagel W Michael Kuehl Louis M Staudt

The oncogene c-maf is translocated in approximately 5%-10% of multiple myelomas. Unexpectedly, we observed c-maf expression in myeloma cell lines lacking c-maf translocations and in 50% of multiple myeloma bone marrow samples. By gene expression profiling, we identified three c-maf target genes: cyclin D2, integrin beta7, and CCR1. c-maf transactivated the cyclin D2 promoter and enhanced myelom...

Journal: :Cancer research 2006
Naoki Morito Keigyou Yoh Yuki Fujioka Takako Nakano Homare Shimohata Yuko Hashimoto Akiko Yamada Atsuko Maeda Fumihiko Matsuno Hiroyuki Hata Atsushi Suzuki Shigehiko Imagawa Hiroaki Mitsuya Hiroyasu Esumi Akio Koyama Masayuki Yamamoto Naoyoshi Mori Satoru Takahashi

c-Maf translocation or overexpression has been observed in human multiple myeloma. Although c-maf might function as an oncogene in multiple myeloma, a role for this gene in other cancers has not been shown. In this study, we have found that mice transgenic for c-Maf whose expression was direct to the T-cell compartment developed T-cell lymphoma. Moreover, we showed that cyclin D2, integrin beta...

2006
R. D. Shaver P. C. Hoffman

Starch, supplied in Midwest diets primarily from high-moisture and dry corn grain and whole-plant corn silage, is an important source of energy for dairy cattle. However, the digestibility of corn starch can be highly variable. Various factors, particle size (fine vs. coarse grind), grain processing (steam flaked vs. dry rolled), storage method (dry vs. high-moisture corn), moisture content of ...

Journal: :Cancer research 2011
Naoki Morito Keigyou Yoh Atsuko Maeda Takako Nakano Akiko Fujita Manabu Kusakabe Michito Hamada Takashi Kudo Kunihiro Yamagata Satoru Takahashi

Multiple myeloma (MM) is a currently incurable neoplasm of terminally differentiated B cells. The translocation and/or overexpression of c-MAF have been observed in human MM. Although c-MAF might function as an oncogene in human MM, there has been no report thus far describing the direct induction of MM by c-MAF overexpression in vivo. In this study, we have generated transgenic (TG) mice that ...

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2011

Immunotherapy has been used for years in many types of cancer therapy. Recently, cancer immunotherapy has focused on mechanisms which can enhance the development of cell-mediated immunity. Anticancer medications are administered to inhibit immunosuppressive factors such as nagalase enzyme, which is produced by neoplastic cells and destroys macrophage activating factor (Gc-MAF). Anti-neoplastics...

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