28 We examined developmental programming studies that reported sex-specific effects 29 published between 2012 and 2014, and examined whether the authors reported a 30 statistical approach to explicitly test whether the effect of treatment differed between the 31 sexes, e.g., a sex by treatment interaction term. Less than half of the studies that reported 32 sex-specific effects described explic...

The planning of large infrastructure projects such as inner-city subway tracks is a highly collaborative process in which numerous experts from different domains are involved. While performing the planning task, widely differing scales have to be taken into consideration, ranging from the kilometer scale for the general routing of the track down to the centimeter scale for the detailed design o...

Phenylketonuria (PKU) is the most common autosomal recessive disorder of amino acid metabolism. Thedisease is caused mainly by mutations in the phenylalanine hydroxylase (PAH) gene, encoding phenylalaninehydroxylase (PAH) enzyme. The PAH enzyme deficiency results in the elevation of phenylalanine inthe blood, which may cause severe irreversible mental retardation in the affect...

For the planning of large infrastructure projects, such as tunnelled inner-city carriageways, completely different scales have to be considered – ranging from the scale of several kilometres for the general routing of the carriageway down to centimetre scale for the detailed planning of track nodes. However, today’s planning software hardly supports multi-scale approaches. The paper presents a ...