Sandra Caldeira is the Editor of the Journal and is at EMBO. European Molecular Biology Organization Heidelberg, Germany E-mail: [email protected] DOI emmm.200900010 Welcome to our new Journal dedicated to the thriving field of Molecular Medicine. EMBO Molecular Medicine publishes original research at the interface between molecular biology and clinical research that is highly relevant to u...

“Blood-Matching Goes Genetic,” a recent News Focus article in Science (1 ), illustrates the growing awareness of the impact of the genomics revolution on transfusion medicine and its potential to transform the way blood is selected for transfusion. Antibody-based technology has been the basis for blood group typing since the discovery of the ABO blood groups by Landsteiner and colleagues. With ...

This issue is devoted to molecular imaging in the context of personalized medicine. Recent advances in biology, particularly genomic and expression screens, have made it possible to hope that treatment can be matched very specifically to the patient’s disease, as characterized at the molecular level. In oncology, where hopes for personalized medicine are perhaps highest, tumors will be treated ...

Over the last few decades, momentous theoretical and technological advancements in the biomedical sciences have enabled an increasingly pervasive and systematic exploration of organisms—including human beings—at the molecular level. This deeper understanding was accompanied by a more accurate and effective manipulation of biological systems which, in turn, underlies a more efficacious and indiv...

1 Department of Biology, Edward Waters College, 1658 Kings Road, Jacksonville, FL 32209, USA 2Department of Biological Sciences, Alabama State University, Room No. 325, Life Science Building 1627, Hall Street, Montgomery, AL 36104, USA 3 College of Pharmacy & Pharmaceutical Sciences, Florida A&M University, 1520 M L King Boulevard, Tallahassee, FL 32307, USA 4Laboratory of General Physiology, D...

Protein folding has numerous steps, which need assistance in vivo. Molecular chaperones are required for many proteins to fold, or re-fold into native structures forming an ancient, primary system for ‘intracellular self-defense’. Molecular chaperones participate in the organization of the cytoarchitecture, were necessary for the development of modern enzymes and—by stabilizing the genome—for t...

Counterfactual reasoning is just as commonplace in scientific theory and practice as it is in our ordinary lives. Understanding the significance of such inferences requires paying close attention to the nature and foundations of conditionals, an important—albeit thorny—endeavor that philosophers of science typically (and happily) delegate to metaphysicians, philosophers of language, and linguis...

The field of biomedical imaging has made significant advances in recent times. This includes extremely high-resolution anatomic imaging and functional imaging of physiologic and pathologic processes as well as novel modalities in optical imaging to evaluate molecular features within the cellular environment. The latter has made it possible to image phenotypic markers of various genotypes that a...

These are exciting times for translational medicine as the convergence between fundamental and clinical research comes of age. The new EMBO Press publishing platform reinforces the standing of EMBO Molecular Medicine as the journal that matches high quality, novel research with rigorous editorial and ethical standards. It will also cement the journal's global reach and relevance whether in high...