Recent progress in radiolabeling of macro- and middle-sized molecular probes has been extending possibilities to use PET imaging for dynamic application drug development therapeutic evaluation. Theranostics concept also accelerated the sharpening contrast proper target recognition even cellular types/subtypes selection patients who should be treated by same molecules recognition. Here, brief su...

Molecular probes, specialized tools or substances meticulously designed to bind specific molecules biomarkers within cells, tissues, biological samples, play a pivotal role in various domains such as biomedical research, diagnostics, and medical treatments [...]

Novel and effective calcium ion binding molecular fluorescent probes have been developed by systematic structural modification of BAPTA ionophore. The comprehensive computational studies suggested the role coordination number in chelator moiety.

by application of modern recombinant dna technology, especially the polymerase chain reaction (pcr)/dot-blot hybridization techniques, we have investigated the molecular basis of β-thalassemia from four different regions of iran: central, south-east, south and north. in this study, the dna samples were isolated from patients and for the identification of the mutations, the 6 oligonucleotide pro...

Molecular imaging is an attractive modality that has been widely employed in many aspects of biomedical research; especially those aimed at the early detection of diseases such as cancer, inflammation and neurodegenerative disorders. The field emerged in response to a new research paradigm in healthcare that seeks to integrate detection capabilities for the prediction and prevention of diseases...

β-secretase (BACE-1), an enzyme critical in the process of amyloid-β (Aβ) peptides deposition in human brain, is closely associated with the onset and progression of Alzheimer's disease (AD). A strong need exists, therefore, to identify molecular imaging probes homing at BACE-1 for use with positron emission tomography (PET) that is recognized as an effective tool for detecting AD. Through this...

Molecular Probes provides a full spectrum of fluorophores and haptens for labeling biopolymers and derivatizing low molecular weight molecules. Chapters 1–5 describe the chemical and spectral properties of the reactive reagents we offer, whereas the remainder of this Handbook is primarily devoted to our diverse collection of fluorescent probes and their applications in cell biology, immunology,...

Molecular beacons are oligonucleotide probes that become fluorescent upon hybridization. We designed molecular beacons to detect a point mutation in the methylenetetrahydrofolate reductase (MTHFR) gene, a mutation that has been related to an increased risk for cardiovascular disease and neural tube defects. The application of molecular beacons enables fast, semiautomated, accurate mutation dete...