نتایج جستجو برای: molecular subtypes
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Breast cancers are comprised of molecularly distinct subtypes that may respond differently to pathway-targeted therapies now under development. Collections of breast cancer cell lines mirror many of the molecular subtypes and pathways found in tumors, suggesting that treatment of cell lines with candidate therapeutic compounds can guide identification of associations between molecular subtypes,...
SUMMARY: Molecular profiling has fundamentally changed our understanding of breast cancer in the last 10 years, by creating a new taxonomy of breast cancers based on the expression patterns of so-called 'intrinsic genes'. Hierarchical clustering analyses performed on microarray-based gene expression profiles of breast cancers defined distinct breast cancer subgroups (luminal type A/B, HER2-enri...
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PURPOSE Breast cancers can display distinct clinical characteristics in different ethnic populations. Previous studies involving European and United States patients have shown that breast tumors can be divided by their gene expression profiles into distinct "molecular subtypes." In this report, we surveyed a series of invasive and preinvasive breast tumors from Asian-Chinese patients to investi...
background: stroke is a heterogeneous disease with several risk factors. high sensitivity c-reactive protein (hscrp) is a marker for cardiovascular and cerebrovascular diseases. recent studies have shown that high hscrp level is a risk factor for ischemic stroke. the objective of our study was to investigate the association of high hscrp (> 3 mg/l) levels with ischemic stroke and its subtypes i...
Background and objectives The prognostic disparities in different molecular subtypes between young Chinese White American breast cancer patients remain unclear. goal of this study was to explore the differences aged ≤ 40 years. Methods We included female at or under age from Surveillance, Epidemiology, End Results database (SEER) West China Hospital Sichuan University. chi-square test, log-rank...
Objective. To investigate prevalence of the A2058G mutation in Russian population T. pallidum and its association with molecular subtypes. Materials Methods. We analyzed DNA isolated from 325 samples clinical material obtained patients dermatovenereological treatment prophylactic institutions 6 federal districts Russia period 2014 to 2021. Patients were diagnosed primary syphilis genital organs...
HER2-positive (HER2+) breast cancer is a clinically and biologically heterogeneous disease. According to gene expression profiling, 4 main intrinsic molecular subtypes of breast cancer (Luminal A, Luminal B, HER2-enriched [HER2-E], Basal-like) can be identified, although HER2-E predominates (~50-60%). From a molecular perspective, HER2-E tumors are characterized by high expression of ERBB2 and ...
INTRODUCTION: Various computational methods for gene expression-based subtyping of highgrade serous (HGS) ovarian cancer have been proposed. This resulted in the identification of molecular subtypes that are based on different datasets and were differentially validated, making it difficult to achieve consensus on which definitions to use in follow-up studies. We assess three major subtype class...
In interdisciplinary biomedical, epidemiologic, and population research, it is increasingly necessary to consider pathogenesis and inherent heterogeneity of any given health condition and outcome. As the unique disease principle implies, no single biomarker can perfectly define disease subtypes. The complex nature of molecular pathology and biology necessitates biostatistical methodologies to s...
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