In the title compound, C(33)H(38)N(4)O(3), the mean planes of the 9H-xanthene unit and spiro-lactam (nine-atom) core are almost mutually perpendicular at 87.26 (6)°. Intra-molecular N-H⋯O and C-H⋯N inter-actions influence the 4-oxo-pent-2-en-2-yl-amino conformation. In the crystal, weak C-H⋯O hydrogen bonds link the mol-ecules into chains along [001].

A tricyclic lactam is reported in a four step synthesis sequence via Beckmann rearrangement and ring-rearrangement metathesis as key steps. Here, we used a simple starting material such as dicyclopentadiene.

MA. The isolation of strains of rickettsiae of the spotted fever group in Israel and their differentiation from other members of the group by immunofluorescence methods. Scand J Infect Dis 1974;6:53-62. 7. Beati L, Finidori JP, Gilot B, Raoult D. Comparison of serologic typing, sodium dodecyl sulfate-polyacrylamide gel electrophore-sis protein analysis, and genetic restriction fragment length p...

Extended-Spectrum Beta-Lactamase (ESBL) are a class of plasmid-mediated diverse, complex and rapidly evolving enzymes which hydrolyzes penicillins, monobactams broad-spectrum cephalosporins. There is increasing prevalence ESBL-producing bacteria globally with higher reported in developing countries. The present study was designed to determine the antimicrobial sensitivity pattern ESBL producing...

The minimum inhibitory concentrations of penicillin and cephalothin necessary to inhibit growth of most anaerobic bacteria were reduced to a susceptible level by 1 to 5 mug of clavulanic acid per ml. In most cases, minimum inhibitory concentrations of cefoxitin were not affected.

The marine alkaloids (-)-lepadins A-C and (+)-lepadin D, belonging to two diastereoisomeric series, were synthesized from an (R)-phenylglycinol-derived tricyclic lactam via a common cis-decahydroquinoline intermediate. Crucial aspects of the synthesis are the stereochemical control in the assembly of the cis-decahydroquinoline platform, in the introduction of the C2 methyl and C3 hydroxy substi...

The bacterial flora of lettuce from western Nigeria were investigated for their identity, antimicrobial resistance, and ability to transfer such resistance to other organisms. The isolated contaminants were mostly Gram-negative organisms of the Enterobacteriaceae family, which included Enterobacter species and E. coli. The organisms were resistant to a wide range of antimicrobials and they exhi...

Aminoglycoside antibiotics bind to the A-site decoding region of bacterial rRNA causing mistranslation and/or premature message termination. Aminoglycoside binding to A-site RNA decoding region constructs is established here to be only weakly stereospecific. Mirror-image prokaryotic A-site decoding region constructs were prepared in the natural D-series and the enantiomeric L-series and tested ...