Monocytes and macrophages belong to the mononuclear phagocyte system play important roles in both physiological pathological processes. The cells belonging monocyte/macrophage are structurally functionally heterogeneous. Several subsets of monocytes have been previously identified mammalian blood, generating different subpopulations tissues. Although their distribution phenotype similar human c...

Flagellates of the genus Leishmania are obligate intracellular parasites of vertebrates including man. The microorganisms reside and multiply inside the phagolysosomes of cells of the mononuclear phagocyte lineage. We here report on the spontaneous leishmanicidal activity exerted extracellularly by immature cells of the mononuclear phagocyte lineage. Highly purified, bone marrow-derived macroph...

of LCH remains unknown. According to molecular study, LCH is not a disease of the epidermal Langerhans cells, but rather one of the myeloid dendritic cells with mononuclear phagocyte dysregulation. The clinical signs and symptoms of LCH vary depending on the organs and extent of involvement. LCH is diagnosed based on pathologic and immunohistochemical evaluation. Histologic features are not pre...

The therapeutic efficacy of systemic drug delivery vehicles is limited by their ability to evade the mononuclear phagocyte system, preferentially localize to the target tissue, and negotiate past the endothelial barrier. In order to create a delivery vehicle capable of all these functions, we developed a biomimetic functionalization of synthetic particles using membranes isolated from leukocyte...

cells of the mononuclear phagocyte system and the dendritic system(l). Each of the histiocytoses of childhood is characterized by localized or generalized, reactive or neoplastic proliferation of cells similar if not identical to one of these cell types(2). As per Writing Group of the Histiocyte Society(3), various histiocytoses of childhood have been classified into Class I, Class II and Class...