Several laboratories have reported studies on individual enzymes that belong to the general class of adenosine triphosphate : nucleoside monophosphate phosphotransferases (EC 2.7.4.4), commonly termed nucleoside monophosphate kinases (l-7). Studies with partially purified enzyme preparations have indicated that a variety of nucleoside monophosphates can serve as alternative substrates for nucle...

In the course of the study of glycolysis in the human red blood cell which is reported in a companion paper (1) new information was collected on the application of column chromatography with anion exchange resins to the isolation of glycolytic intermediates and related compounds. The findings are the subject of this communication. Included in this report are modifications of some analytical met...

Nine dinucleoside phosphates containing 1-deaza-(1A) and 3-deazaadenosine (3A) were prepared. Hypochromicity and CD spectra of these dimers were determined. It was found that varying degrees of base-stacking are operative with these oligonucleotides and their CD spectra fall into three classes. The first class CD spectra which are more or less similar in profile to those of adenylyl-(3'-5')-ade...

In the course of the study of glycolysis in the human red blood cell which is reported in a companion paper (1) new information was collected on the application of column chromatography with anion exchange resins to the isolation of glycolytic intermediates and related compounds. The findings are the subject of this communication. Included in this report are modifications of some analytical met...

Ethidium and isometamidium induce the breakdown of intracellular adenosine triphosphate in Ehrlich ascites tumor cells incubated in vitro. Ethidium induces appreciable adenosine triphosphate breakdown only when cells are incubated without glucose, whereas isometamidium produces this effect both in the presence and absence of glucose. In cells treated with isometamidium, purine nucleoside monoph...