Abnormal L-type Ca(2+) channel (LTCC, also named Cav1.2) density and regulation are important contributors to depressed contractility in failing hearts. The LTCC agonist BAY K 8644 (BAY K) has reduced inotropic effects on failing myocardium. We hypothesized that BAY K effects on the LTCC current (I(CaL)) in failing myocytes would be reduced because of increased basal activity. Since support of ...

BAY 41-2272 (BAY), a stimulator of soluble guanylyl cyclase, increases cyclic nucleotides and inhibits proliferation of vascular smooth muscle cells (VSMCs). In this study, we elucidated mechanisms of action of BAY in its regulation of vasodilator-stimulated phosphoprotein (VASP) with an emphasis on VSMC phosphodiesterases (PDEs). BAY alone increased phosphorylation of VASP(Ser239) and VASP(Ser...

Replication is a fundamental pillar in the construction of scientific knowledge. Test data generation for procedural programs can be tackled using a single-target or a many-objective approach. The proponents of LIPS, a novel single-target test generator, conducted a preliminary empirical study to compare their approach with MOSA, an alternative many-objective test generator. However, their empi...

Corresponding Author: Qusay Omran Mosa Faculty of Information Science and Technology, University Kebangsaan Malaysia, Malaysia Email: [email protected] Abstract: Active contours also known as snakes became a familiar and widely used in the field of image segmentation and restoration of historical documents in last few decades. Gradient Vector Flow (GVF) snake successes in overcome of converge...

This chapter presents the application of a comprehensive statistical analysis for both algorithmic performance comparison and optimal parameter estimation on a multi-objective digital signal processing problem. The problem of designing optimum digital finite impulse response (FIR) filters with the simultaneous approximation of the filter magnitude and phase is posed as a multiobjective optimiza...

Data on characteristics of metal-oxide surge arresters indicates that for fast front surges, those with rise times less than 8μs, the peak of the voltage wave occurs before the peak of the current wave and the residual voltage across the arrester increases as the time to crest of the arrester discharge current decreases. Several models have been proposed to simulate this frequency-dependent cha...

In this paper, a multiobjective simulated annealing (MOSA) method is introduced and discussed with the multiobjective evolutionary algorithms (MOEAs). Though the simulated annealing is a very powerful search algorithm and has shown good results in various singleobjective optimization fields, it has been seldom used for the multiobjective optimization because it conventionally uses only one sear...

Vehicular Networks are receiving a lot of attention due to the wide variety of services they can provide. Their applications range from safety and crash avoidance to Internet access and multimedia. A lot of work and research around the globe is being conducted to define the standards for vehicular communications. These include frequency allocation, standards for physical and link layers, routin...

Integrated production-distribution planning (PDP) is one of the most important approaches in supply chain networks. We consider a supply chain network (SCN) consististing of multi suppliers, plants, distribution centers (DCs), and retailers. A bi-objective mixed integer linear programming model for integrating production-distribution designed here aim to simultaneously minimize total net costs ...