Equine motor neuron disease (EMND) is an acquired neuromuscular disease of horses that was first recognized in 1985 and reported in a preliminary report often horses in 1 990.3 The disease is characterized pathologically by degeneration of motor neurons in the ventral horns of the spinal cord and in selected brain stem nuclei. Death of motor neurons results in secondary axonal degeneration and ...

Background: The existing diagnostic criteria for definite, probable and possible amyotrophic lateral sclerosis (ALS) require at least one upper motor neuron (UMN) sign. However, we think some cases of ALS or motor neuron disease may be not able to fulfill the required criteria. We investigated whether the clinical presentation and course of patients with ALS or motor neuron disease fulfill the ...

background: als is the most devastating form of motor neuron disease, and the chance of survival is 3 to 5 years after the diagnosis is made. the pathogenesis of the disease is unknown. several upper and lower motor neuron symptoms such as weakness, gait bradykinesia, and muscle atrophy have been reported. the core muscles are considered to be the center of the functional kinetic chain due to t...

ALS is a fatal neurodegenerative disease characterized by a progressive loss of motor neurons and atrophy of distal axon terminals in muscle, resulting in loss of motor function. Motor end plates denervated by axonal retraction of dying motor neurons are partially reinnervated by remaining viable motor neurons; however, this axonal sprouting is insufficient to compensate for motor neuron loss. ...

Two patients presenting with progressive dementia coupled with motor neuron disease underwent brain SPECT using N-isopropyl-p iodine-123-iodoamphetamine [( 123I]IMP). The characteristic clinical features of progressive dementia and motor neuron disease were noted. IMP SPECT also revealed reduced uptake in the bilateral frontal and temporal regions, with no reduction of uptake in the parietal, p...

Introduction: The term motor neuron disease encompasses a spectrum of disorders in which motor neurons are the lost. Importantly, while some motor neurons are lost early in disease and others remain intact at disease end-stage. This creates a valuable experimental paradigm to investigate the factors that regulate motor neuron vulnerability. Spinal muscular atrophy is a childhood motor neuron di...

Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a form of human motor neuron disease. In addition, mutations in the molecular motors dynein and kinesins and several proteins associated with the me...