PURPOSE To investigate the feasibility of performing multisection proton MR spectroscopy in patients with acute stroke, and to determine whether this imaging technique can depict ischemic or infarcted brain regions. METHODS Multisection proton MR spectroscopy, MR imaging, and MR angiography were performed within 24 hours of stroke onset (mean, 12 hours) in 12 patients who had had a stroke of ...

Pediatric bipolar disorder is a severe mental illness whose pathophysiology is poorly understood and for which there is an urgent need for improved diagnosis and treatment. MR spectroscopy is a neuroimaging method capable of in vivo measurement of neurochemicals relevant to bipolar disorder neurobiology. MR spectroscopy studies of adult bipolar disorder provide consistent evidence for alteratio...

BACKGROUND AND PURPOSE The characterization of peripheral nerve sheath tumors is challenging. The purpose here was to investigate the diagnostic value of quantitative proton MR spectroscopy at 3T for the characterization of peripheral nerve sheath tumors as benign or malignant, compared with PET. MATERIALS AND METHODS Twenty participants with 24 peripheral nerve sheath tumors underwent MR spe...

In vivo proton magnetic resonance (MR) spectroscopy (hydrogen 1 spectroscopy) provides useful information about the pathology of breast lesions by the measurement of diagnostic chemicals visible on the MR timescale. Spectroscopic measurements may be obtained following contrast-enhanced MR imaging by applying a point-resolved spatially localized spectroscopy sequence. The observation of resonanc...

K.K. Oguz A. Kurne A.O. Aksu E. Karabulut A. Serdaroglu S. Teber S. Haspolat N. Senbil S. Kurul B. Anlar BACKGROUND AND PURPOSE: Myelin instability and citrullinated myelin basic protein have been demonstrated in the brains of patients with chronic and fulminating forms of multiple sclerosis (MS). Our aim was to trace citrulline in the brains of patients with early-onset MS by using proton MR s...

BACKGROUND AND PURPOSE The combination of nonspecific clinical findings and similarities in morphologic appearances on imaging often makes it difficult to distinguish abscesses from other brain lesions. We present a retrospective analysis of in vivo (1)H-MR spectroscopy data for characterization of the etiology of the brain abscess based on the established criteria and demonstrate the sensitivi...

Purpose: To evaluate both a histogram based analysis of MR-derived cerebral blood volume maps and metabolite ratios from proton MR spectroscopy in order to exploit the ability of each method to characterize gliomas and to evaluate their combined diagnostic potential. Background: The value of normalized cerebral blood volume ratio (nCBV) analysis to differentiate high-grade (WHO grade III-IV) fr...

BACKGROUND AND PURPOSE Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, inflammatory neurodegenerative disease. Our aim was to determine the metabolic abnormalities of brain in early- and late-stage SSPE by using MR spectroscopy and to assess areas of involvement in the early stages when MR imaging findings were normal. METHODS Children with stage II (n = 3) or III (n = 3) S...