Multiple sclerosis (MS) is an inflammatory and autoimmune disease.MS is characterized by blood brain barrier breakdown, inflammation, axonal injury, degeneration of the myelin sheath and etc. A significant association between inflammation and degeneration of neurons is observed in the brain. Also active MS lesions always associated with inflammation thus inflammation is a target for treatment o...

BACKGROUND Multiple sclerosis (MS) is an autoimmune disease, in which the insulating covers of nerve cells in the brain and spinal cord are demyelinated. This study was conducted to compare the efficacy of alemtuzumab and natalizumab in the treatment of different stages of MS patients. METHODS A total of 585 patients diagnosed with MS and hospitalized were included and analyzed after which th...

Multiple Sclerosis (MS) is an autoimmune disease, which is characterized by demyelination and neuroinflammation. Extracellular Matrix (ECM) have important role in the central nervous system (CNS). Alterations are happening to the ECM after the CNS disorder like MS, Alzheimer and other neural injury. Tenasin-C (TnC) is a glycoprotein that is highly expressed in inflammatory conditions of the CNS...

OBJECTIVE To constitute the third revision of the guidelines for the treatment of bipolar disorder issued by the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP 2014). METHODS A 56-item questionnaire was used to obtain the consensus of experts regarding pharmacological treatment strategies for the various phases of bipolar disorder and for special populations. The review com...

abstract to produce embryogenic callus and somatic embryo, whole flower explants were collected at two sampling stages of i, iii. to produce embryogenic callus and somatic embryo, ms medium supplemented with 5 and 10µm 2,4-d and 2µm bap were used. for embryo differentiation, ms medium with 0.5mg/l iba, ms medium without any plant growth regulators, ms medium with 2mg/l iba and 0.2mg/l bap, ms m...

background: cognitive  impairment  is one of the  most crucial disorders  among  multiple  sclerosis (ms) patients. since  ms  is  an inflammatory disease   and   boswellia papyrifera has anti-inflammatory effects, the influence of b. papyrifera  on  cognitive  impairment   in  ms patients   has been investigated  in the present study. methods: in this clinical trial, 80 ms patients  who referr...

BACKGROUND Managing multiple sclerosis (MS) treatment presents challenges for both patients and health care professionals. Effective communication between patients with MS and their neurologist is important for improving clinical outcomes and quality of life. METHODS A closed-ended online market research survey was used to assess the current state of MS care from the perspective of both patie...

No Treatment for a Long Time Position The neurologists and the National MS Societies (e.g. MS Society of Canada, NMSS) have taken the stance that persons with MS should not get tested and treated for MS until proper research which clearly demonstrates the effectiveness of such treatment is done and published. The rationale for this position is that we do not know if such treatment will be helpf...

In trees adapted to cold climates, conditions during autumn and winter may influence the subsequent timing of bud burst and hence tree survival during early spring frosts. We tested the effects of two temperatures during dormancy induction and mild spells (MS) during chilling on the timing of bud burst in three Picea abies (L.) Karst. provenances (58-66 degrees N). One-year-old seedlings were i...

Background: Beneficial effects of vitamins and dietary supplements in the prevention and treatment of metabolic syndrome (MS) are controversial. This study aims to evaluate the association between dietary supplements intake and MS. Methods: This analytical cross-sectional analysis was conducted on 9539 people aged 35-70 years who participated in the recruitment phase of Shahedieh Cohort Study i...