Extraction of the mid-sagittal plane (MSP) is an important step for brain image registration and asymmetry analysis. We present a fast MSP extraction method for 3D MR images, which is based on automatic segmentation of the brain and on heuristic maximization of cerebro-spinal fluid within the MSP. The method is shown to be robust to severe anatomical asymmetries between the hemispheres, caused ...

Java Music Specification Language (Didkovsky, Burk 2001) is a Java package for algorithmic music composition, notation, and interactive performance. Max/MSP (Puckette, Zicarelli) is a graphical environment for music, audio, and multimedia. The introduction of a Java API to Max/MSP offers new possibilities for rich interaction between JMSL and Max. This paper presents new tools for bidirectional...

INTRODUCTION Metastasis is a crucial aspect of cancer. Macrophage stimulating protein (MSP) is a single chain protein and can be cleaved by serum proteases. MSP has several roles in metastasis. In this in silico study, MSP as a metastatic agent was considered as a drug target. METHODS Crystallographic structure of MSP was retrieved from protein data bank. To find a chemical inhibitor of MSP, ...

Macrophage-stimulating protein (MSP) promotes the phagocytosis of C3bi-coated erythrocytes by resident peritoneal macrophages, although the mechanism by which this occurs is largely unknown. We show that MSP-induced complement-mediated phagocytosis requires the RON receptor tyrosine kinase and the alphaMbeta2 integrin, as evidenced by the inability of RON-/- and alphaM-/- peritoneal macrophages...

O6-Methylguanine-DNA methyltransferase (MGMT) promoter hypermethylation has recently emerged as a powerful determinant of chemotherapy sensitivity in glioblastomas. To adapt such an important epigenetic biomarker to routine application in the clinical setting, we validated the conventionally used methylation-specific polymerase chain reaction (MSP) assay for its relevance in the determination o...

A multidisciplinary method combining transcriptional data, specificity profiling, and biological characterization of an enzyme may be used to predict novel substrates. By integrating protease substrate profiling with microarray gene coexpression data from nearly 2,000 human normal and cancerous tissue samples, three fundamental components of a protease-activated signaling pathway were identifie...

Multi-stage programming (MSP) is a paradigm for developing generic software that does not pay a runtime penalty for this generality. This is achieved through concisely, carefully designed language extensions that support runtime code generation and program execution. Additionally, type systems for MSP languages are designed to statically ensure that dynamically generated programs are type safe ...

We discuss and evaluate the Multi-State Plan (MSP) Program, a provision of the Affordable Care Act that has not been the subject of much debate as yet. The MSP Program provides the Office of Personnel Management with new authority to negotiate and implement multistate insurance plans on all health insurance exchanges within the United States. We raise the concern that the MSP Program may lead t...

Form follows function, and this maxim is particularly true for the nematode sperm cell. Motility is essential for fertilization, and the process of spermatogenesis culminates in the production of a crawling spermatozoon with an extended pseudopod. However, the morphological similarity to amoeboid cells of other organisms is not conserved at the molecular level. Instead of utilizing the actin cy...

Macrophage-stimulating protein (MSP) promotes the phagocytosis of C3bi-coated erythrocytes by resident peritoneal macrophages, although the mechanism by which this occurs is largely unknown. We show that MSP-induced complement-mediated phagocytosis requires the reorienting negativity (RON) receptor tyrosine kinase and the M 2 integrin, as evidenced by the inability of RON / and M / peritoneal m...