نتایج جستجو برای: msra

تعداد نتایج: 346  

2011
Yunbo Cao Chin-Yew Lin Guoqing Zheng

The Knowledge Base Population task aims at advancing the state of the art for systems that automatically discover information about named entities and then incorporate this information in a knowledge source. The overall task of populating a knowledge base is decomposed into two related tasks: Entity Linking, where names must be aligned to entities in the KB, and Slot Filling, which involves min...

2013
Kazuya Narita Tetsuya Sakai Zhicheng Dou Young-In Song

We describe Microsoft Research Asia’s approaches to the NTCIR-10 1CLICK-2 task. We construct the system based on some heuristic rules, and change the setting of our approaches to test the effectiveness of each setting. The evaluation results show the effectiveness of the query attributes.

Journal: :MATEC web of conferences 2021

Nowadays, most deep learning models ignore Chinese habits and global information when processing tasks. To solve this problem, we constructed the BERT-BiLSTM-Attention-CRF model. In model, embeded BERT pre-training language model that adopts Whole Word Mask strategy, added a document-level attention. Experimental results show our method achieves good in MSRA corpus, F1 reaches 95.00%.

2011
Dorthe S. Bille Karina Banasik Johanne M. Justesen Camilla H. Sandholt Annelli Sandbæk Torsten Lauritzen Torben Jørgensen Daniel R. Witte Jens-Christian Holm Torben Hansen Oluf Pedersen

BACKGROUND Two meta-analyses of genome-wide association studies (GWAS) have suggested that four variants: rs2605100 in lysophospholipase-like 1 (LYPLAL1), rs10146997 in neuroxin 3 (NRXN3), rs545854 in methionine sulfoxide reductase A (MSRA), and rs987237 in transcription factor activating enhancer-binding protein 2 beta (TFAP2B) associate with measures of central obesity. To elucidate potential...

Saliency regions attract more human’s attention than other regions in an image. Low- level and high-level features are utilized in saliency region detection. Low-level features contain primitive information such as color or texture while high-level features usually consider visual systems. Recently, some salient region detection methods have been proposed based on only low-level features or hig...

Journal: :Antimicrobial agents and chemotherapy 2005
Kepler A Davis Sharon A Crawford Kristin R Fiebelkorn James H Jorgensen

Staphylococcal isolates were examined for possible macrolide-inducible resistance to telithromycin. All macrolide-resistant isolates demonstrated telithromycin D-shaped zones. This result did not discriminate between resistance due to an efflux mechanism (msrA) or a ribosomal target modification (ermA or ermC). Inducible telithromycin resistance in staphylococci does not appear to be analogous ...

Journal: :Investigative ophthalmology & visual science 2005
Maria A Marchetti Gresin O Pizarro Daphna Sagher Candida Deamicis Nathan Brot J Fielding Hejtmancik Herbert Weissbach Marc Kantorow

PURPOSE Methionine-sulfoxide reductases are unique, in that their ability to repair oxidized proteins and MsrA, which reduces S-methionine sulfoxide, can protect lens cells against oxidative stress damage. To date, the roles of MsrB1, -B2 and -B3 which reduce R-methionine sulfoxide have not been established for any mammalian system. The present study was undertaken to identify those MsrBs expre...

2015
Vineet K. Singh Manisha Vaish Trintje R. Johansson Kyle R. Baum Robert P. Ring Saumya Singh Sanjay K. Shukla Jackob Moskovitz

Staphylococcus aureus is a major human pathogen and emergence of antibiotic resistance in clinical staphylococcal isolates raises concerns about our ability to control these infections. Cell wall-active antibiotics cause elevated synthesis of methionine sulfoxide reductases (Msrs: MsrA1 and MsrB) in S. aureus. MsrA and MsrB enzymes reduce S-epimers and R-epimers of methionine sulfoxide, respect...

Journal: :The Journal of biological chemistry 2002
R Abhilash Kumar Ahmet Koc Ronald L Cerny Vadim N Gladyshev

Methionine residues in proteins are susceptible to oxidation, and the resulting methionine sulfoxides can be reduced back to methionines by methionine-S-sulfoxide reductase (MsrA) and methionine-R-sulfoxide reductase (MsrB). Herein, we have identified two MsrB families that differ by the presence of zinc. Evolutionary analyses suggested that the zinc-containing MsrB proteins are prototype enzym...

2010
André Scherag Christian Dina Anke Hinney Vincent Vatin Susann Scherag Carla I. G. Vogel Timo D. Müller Harald Grallert H.-Erich Wichmann Beverley Balkau Barbara Heude Marjo-Riitta Jarvelin Anna-Liisa Hartikainen Claire Levy-Marchal Jacques Weill Jérôme Delplanque Antje Körner Wieland Kiess Peter Kovacs Nigel W. Rayner Inga Prokopenko Mark I. McCarthy Helmut Schäfer Ivonne Jarick Heiner Boeing Eva Fisher Thomas Reinehr Joachim Heinrich Peter Rzehak Dietrich Berdel Michael Borte Heike Biebermann Heiko Krude Dieter Rosskopf Christian Rimmbach Winfried Rief Tobias Fromme Martin Klingenspor Annette Schürmann Nadja Schulz Markus M. Nöthen Thomas W. Mühleisen Raimund Erbel Karl-Heinz Jöckel Susanne Moebus Tanja Boes Thomas Illig Philippe Froguel Johannes Hebebrand David Meyre

Meta-analyses of population-based genome-wide association studies (GWAS) in adults have recently led to the detection of new genetic loci for obesity. Here we aimed to discover additional obesity loci in extremely obese children and adolescents. We also investigated if these results generalize by estimating the effects of these obesity loci in adults and in population-based samples including bo...

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