A phase I study was conducted to determine the dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) for the combination of vorinostat with bevacizumab and CPT-11 in recurrent glioblastoma. Vorinostat was combined with bevacizumab and CPT-11 and was escalated using a standard 3 + 3 design. Vorinostat was escalated up to 2 actively investigated doses of this compound or until the MTD w...

Previous studies with temozolomide suggest that a prolonged duration of chemotherapy is important for treating low-grade gliomas (LGGs). PCV (procarbazine, CCNU, vincristine) chemotherapy has demonstrated efficacy in treating LGGs, but this therapy cannot be used for a prolonged period because of the cumulative toxicity. The aim of the present study was to evaluate the impact of first-line PCV ...

We studied the role of chemotherapy in cancer cachexia, which is well known to lower QOL and responsiveness to chemotherapy. In BALB/c mice we used two clones derived from the murine colon 26 adenocarcinoma cell line; clone 5, a non-cachexigenic tumor and clone 20, a cachexigenic tumor, in which IL-6 mRNA was selectively detected. While maximum tolerated dose (MTD) of CPM and CPT-11 showed sign...

The objective is to evaluate in situ detection of living mycobacterium tuberculosis rRNA using Mycobacterium Tuberculosis Direct Assay (MTD) and its clinical significance in early diagnosis of extrapulmonary tuberculosis. 86 patients having been diagnosed to have extrapulmonary tuberculosis including tuberculous peritonitis (n=22), lymphatic tuberculosis (n=21), tuberculous meningitis (n=15), H...

We reported previously that spline interpolation is effective as a pretreatment before analyzing clinical data by time series. However, further improvement is required to understand the detailed tendency of clinical data. In this study, the tendency of interpolated hematological data was investigated in the period between the most tolerated dose (MTD) and low-dose chemotherapy (LDC) for colorec...

OBJECTIVES/HYPOTHESIS To determine whether radiographic measures of hyoid position, laryngeal position, and hyolaryngeal space during phonation were different for people with primary muscle tension dysphonia (MTD) as compared to control participants without voice disorders. STUDY DESIGN Prospective, quasi-experimental research design. METHODS Twenty participants, 10 with primary MTD and 10 ...

The fundamental premise behind Moving Target Defense (MTD) is to create a dynamic and shifting system that is more difficult to attack than a static system because a constantly changing attack surface at least reduces the chance of an attacker finding and exploiting the weakness. However, MTD approaches are typically chosen without regard to other qualities of the system, such as performance or...

For the Phase-2 upgrade, CMS experiment foresees installation of a MIP Timing Detector (MTD) to assign precise timestamp every charged particle up pseudorapidity | η = 3 , empowering detector with unique and new capabilities. The target timing resolution MTD less than 40 ps per track will mitigate effects severe pile-up expected at High-Luminosity LHC, maintaining performances similar current L...

Fast and accurate detection of cyberattacks is a key element for cyber-resilient power system. Recently, data-driven detectors physics-based Moving Target Defences (MTD) have been proposed to detect false data injection (FDI) attacks on state estimation. However, the uncontrollable positive rate detector extra cost frequent MTD usage limit their wide applications. Few works explored overlap bet...

Classical mitochondrial diseases occur in a subset of individuals with autism and are usually caused by genetic anomalies or mitochondrial respiratory pathway deficits. However, in many cases of autism, there is evidence of mitochondrial dysfunction (MtD) without the classic features associated with mitochondrial disease. MtD appears to be more common in autism and presents with less severe sig...